Kerryn E Pike, Sian E B Virtue-Griffiths, Rachel Campbell, Dianne M Legge, Katarzyna Lion, Carl I Moller, Tamara Ownsworth, Mark B Pinkham, Louise Saliba, Ursula M Sansom-Daly, Dean Vuksanovic, Joanne Shaw, Haryana M Dhillon
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Adults > 3-months post-PBT diagnosis, and > 1-month post-radiation were randomized to (1) Intervention [6-week group sessions; 2 hours/week], delivered over Zoom (<i>n</i> = 3-7/group) or (2) WLC (intervention offered at 16 weeks). Primary outcomes were self-perceived memory (ability, strategy knowledge and use, satisfaction) and general cognitive function; secondary outcomes included QoL, fatigue, mood, and objective cognition (attention, working memory, processing speed, memory, executive function). Linear mixed models analyzed between-group differences post-intervention and 6 weeks later (maintenance).</p><p><strong>Results: </strong>Sixty participants (<i>M(SD)</i> age = 49.0 (10.4) years, 57% female, 55% high-grade glioma) were randomized (29 intervention, 31 WLC). The intervention group reported significantly improved perceived memory ability, satisfaction, strategy use, and strategy knowledge. Effect sizes were moderate-large (ηp<sup>2</sup> 0.06-0.21), and maintained for memory ability (<i>t</i> = 4.26, <i>P</i> < .001, ηp<sup>2</sup> = 0.18), satisfaction (<i>t</i> = 2.23, <i>P</i> = .028, ηp<sup>2</sup> = 0.18), and strategy knowledge (<i>t</i> = 2.92, <i>P</i> = .004, ηp<sup>2</sup> = 0.09). Secondary outcomes exhibited no intervention effect.</p><p><strong>Conclusions: </strong>Telehealth-delivered LaTCH-BRAINS improved subjective memory-related outcomes for people with PBT, demonstrating promise as a cognitive rehabilitation approach for people with PBT reporting memory decline.</p><p><strong>Trial registration: </strong>Australian New Zealand Clinical Trials Registry (ACTRN 12622000189729p), registered on 03/02/2022 (Appendix A).</p>","PeriodicalId":94157,"journal":{"name":"Neuro-oncology advances","volume":"7 1","pages":"vdaf182"},"PeriodicalIF":4.1000,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12448700/pdf/","citationCount":"0","resultStr":"{\"title\":\"A randomized controlled trial of a telehealth group cognitive intervention (LaTCH-BRAINS) to improve cognition after primary brain tumor diagnosis.\",\"authors\":\"Kerryn E Pike, Sian E B Virtue-Griffiths, Rachel Campbell, Dianne M Legge, Katarzyna Lion, Carl I Moller, Tamara Ownsworth, Mark B Pinkham, Louise Saliba, Ursula M Sansom-Daly, Dean Vuksanovic, Joanne Shaw, Haryana M Dhillon\",\"doi\":\"10.1093/noajnl/vdaf182\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Cognitive changes are common following primary brain tumor (PBT), impacting employment, independence, relationships, and quality of life (QoL). 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引用次数: 0
摘要
背景：认知变化是原发性脑肿瘤（PBT）后常见的，影响就业、独立、人际关系和生活质量（QoL）。尽管如此，量身定制的认知干预在澳大利亚是不可用的。拉特罗布和考尔菲尔德医院（LaTCH）的群体认知康复项目已经证明对没有PBT的老年人有效。对PBT患者的疗效采用远程医疗闩锁进行检查。方法：采用1型混合实施设计随机对照试验（RCT）和等待名单对照（WLC）。诊断pbt后3个月>和放疗后1个月>的成年人随机分为(1)干预组[6周组]；2小时/周]，通过Zoom （n = 3-7/组）或(2)WLC（在16周时提供干预）交付。主要结果为自我感知记忆（能力、策略知识和使用、满意度）和一般认知功能；次要结果包括生活质量、疲劳、情绪和客观认知（注意力、工作记忆、处理速度、记忆力、执行功能）。线性混合模型分析干预后和6周后（维持）组间差异。结果：60名参与者（M（SD）年龄= 49.0（10.4）岁，57%为女性，55%为高级别胶质瘤）被随机分组（29名干预，31名WLC）。干预组报告知觉记忆能力、满意度、策略使用和策略知识显著提高。记忆能力（t = 4.26, P 2 = 0.18）、满意度（t = 2.23, P = 0.18）的效应量均为中-大（ηp2 = 0.06-0.21）。028、ηp2 = 0.18)和策略知识(t = 2.92, P =。004, ηp2 = 0.09)。次要结局没有干预效果。结论：远程医疗提供的LaTCH-BRAINS改善了PBT患者的主观记忆相关结果，为报告记忆衰退的PBT患者提供了一种认知康复方法。试验注册：澳大利亚新西兰临床试验注册中心（ACTRN 12622000189729p），注册时间为2022年2月3日（附录A）。
A randomized controlled trial of a telehealth group cognitive intervention (LaTCH-BRAINS) to improve cognition after primary brain tumor diagnosis.
Background: Cognitive changes are common following primary brain tumor (PBT), impacting employment, independence, relationships, and quality of life (QoL). Despite this, tailored cognitive interventions are unavailable within Australia. The La Trobe and Caulfield Hospital (LaTCH) group cognitive rehabilitation program has demonstrated efficacy for older adults without PBT. Efficacy for people with PBT was examined using a telehealth adaption of LaTCH.
Methods: A Type 1 hybrid-implementation design randomized controlled trial (RCT) with waitlist control (WLC) was used. Adults > 3-months post-PBT diagnosis, and > 1-month post-radiation were randomized to (1) Intervention [6-week group sessions; 2 hours/week], delivered over Zoom (n = 3-7/group) or (2) WLC (intervention offered at 16 weeks). Primary outcomes were self-perceived memory (ability, strategy knowledge and use, satisfaction) and general cognitive function; secondary outcomes included QoL, fatigue, mood, and objective cognition (attention, working memory, processing speed, memory, executive function). Linear mixed models analyzed between-group differences post-intervention and 6 weeks later (maintenance).
Results: Sixty participants (M(SD) age = 49.0 (10.4) years, 57% female, 55% high-grade glioma) were randomized (29 intervention, 31 WLC). The intervention group reported significantly improved perceived memory ability, satisfaction, strategy use, and strategy knowledge. Effect sizes were moderate-large (ηp2 0.06-0.21), and maintained for memory ability (t = 4.26, P < .001, ηp2 = 0.18), satisfaction (t = 2.23, P = .028, ηp2 = 0.18), and strategy knowledge (t = 2.92, P = .004, ηp2 = 0.09). Secondary outcomes exhibited no intervention effect.
Conclusions: Telehealth-delivered LaTCH-BRAINS improved subjective memory-related outcomes for people with PBT, demonstrating promise as a cognitive rehabilitation approach for people with PBT reporting memory decline.
Trial registration: Australian New Zealand Clinical Trials Registry (ACTRN 12622000189729p), registered on 03/02/2022 (Appendix A).
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