系统性红斑狼疮的紧张症。

IF 2 Q3 CLINICAL NEUROLOGY
NeuroSci Pub Date : 2025-09-09 DOI:10.3390/neurosci6030090
Ciro Manzo, Jordi Serra-Mestres, Marco Isetta
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引用次数: 0

摘要

背景:系统性红斑狼疮(SLE)被报道为与紧张症相关的最常见的风湿病。迄今为止,关于SLE患者紧张症表现的报道在已发表的文献中并不常见,通常倾向于碎片化的视觉。我们进行了一项叙述性回顾,目的是确定所有已发表的SLE患者紧张症的报告,以全面确定其临床特征,并为日常临床实践提供有用的见解。方法:于2025年3月10日在所有主要书目数据库(MEDLINE和EMBASE (OVID接口))中进行综合文献检索(随后在6月6日草案之前重复);PsycINFO(它);和PubMed,以捕获文本内引用。所有的搜索都结合了受控(MESH, Entree和APA标题)和自由文本元素,用于观察两个领域:系统性红斑狼疮(SLE)和紧张症,主要集中在病例报告和系列。每组研究结果分别由作者进行评审,选定项目的全文均有来源。通过引文列表检索到更多有用的参考文献。结果:共发现SLE合并紧张症患者39例(女35例,男4例),平均年龄22.64岁(范围11-46岁)。年龄在40岁以上的只有3例;10例患者在SLE发病时出现紧张症,5例患者在SLE诊断后一个月内出现紧张症。抗磷脂和抗核糖体P蛋白抗体很少被发现。在劳拉西泮和/或电休克治疗后,几乎所有患者的症状都有所改善。报告恶性紧张症1例。最后,大量患者是亚洲人或非裔美国人,至少在指定种族的报告中是这样。结论:SLE患者可出现紧张症,且紧张症可能是SLE的首要临床表现,尤其是年轻患者。它的预后大多是有利的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Catatonia in Systemic Lupus Erythematosus.

Background: Systemic lupus erythematosus (SLE) is reported to be the most common rheumatological disorder associated with catatonia. To date, reports on catatonia manifestations in SLE patients are uncommon in published literature, which has often favored a fragmented vision. We performed a narrative review with the aim of identifying all published reports of catatonia in SLE patients to ascertain-in a comprehensive view-its clinical characteristics and to provide useful insights for daily clinical practice.

Methods: Comprehensive literature searches were carried out on 10 March 2025 (subsequently repeated ahead of draft on 6 June) in all main bibliographic databases: MEDLINE and EMBASE (OVID interface); PsycINFO (ProQuest); and PubMed, to capture within-text references. All searches combined controlled (MESH, Entree, and APA Headings) and free-text elements for both areas under observation: systemic lupus erythematosus (SLE) AND catatonia, with primary focus on case reports and series. Sets of findings were reviewed separately by the authors, and the full text of selected items was sourced. Further useful references were retrieved through citation lists.

Results: 39 cases of patients with SLE and catatonia were identified (35 females and 4 males), with a mean age of 22.64 years (range 11-46). Only three patients were over the age of 40; a total of 10 had catatonia at the same time of SLE onset and 5 within a month of SLE diagnosis. Antiphospholipid and anti-ribosomal P protein antibodies were rarely identified. Almost all the patients improved following treatment with lorazepam and/or electroconvulsive therapy. Only one case of malignant catatonia was reported. Finally, a large number of patients were Asian or Afro-American, at least in the reports where ethnicity was specified.

Conclusions: Catatonia can occur in patients with SLE, and it may be its first clinical manifestation, especially in young patients. Its prognosis is mostly favorable.

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