ExoTMS transcranial magnetic stimulation for the reduction of binge eating symptoms.

Aim: Transcranial magnetic stimulation (TMS) is an emerging treatment for binge eating (BE). TMS uses noninvasive magnetic pulses to stimulate the prefrontal cortex, which plays a role in decision-making and self-regulation. Early research suggests that TMS can reduce BE episodes by modulating brain activity linked to cravings and compulsive behavior. This article aims to evaluate the efficacy and safety of a novel TMS device with ExoTMS™ Technology for alleviating BE symptoms.

Methods: Subjects underwent six TMS sessions and a 1-month follow-up. The Binge Eating Scale (BES) was administered at baseline, posttreatment, and follow-up to assess symptom severity. Weight was recorded at the same intervals. Therapy comfort was evaluated after the sixth session. The Subject Satisfaction Questionnaire was completed posttreatment and at follow-up. Adverse events and side effects were monitored throughout the study. Data from two identically designed studies were pooled for analysis.

Results: A total of 38 subjects were analyzed. BES scores significantly decreased posttreatment (-37.8%, p < 0.001) and at follow-up (-47.9%, p < 0.001). At 1 month, 73.7% of subjects achieved BE remission. Average weight loss was -1.3 ± 1.1 kg posttreatment and -1.8 ± 1.3 kg at follow-up. Comfort was rated positively by 92.1% of participants. At follow-up, 89.5% reported reduced cravings and snacking, 86.8% noted improved self-control and well-being, and 94.7% were satisfied with the treatment.

Conclusion: TMS shows promise as a safe and effective intervention for reducing BE symptoms, supported by both objective clinical measures and subjective patient-reported outcomes.