Sana Irshad, Parth Adrejiya, Mohammad Abubaker, Theophilus Adatsi, Oluchi Idenyi, Srikanth Maddika, Swathi Gorle, Abhishek Thandra, Srinivasa R Chennareddy
{"title":"大麻诱导的年轻人心脏骤停:一例报告。","authors":"Sana Irshad, Parth Adrejiya, Mohammad Abubaker, Theophilus Adatsi, Oluchi Idenyi, Srikanth Maddika, Swathi Gorle, Abhishek Thandra, Srinivasa R Chennareddy","doi":"10.12659/AJCR.950077","DOIUrl":null,"url":null,"abstract":"<p><p>BACKGROUND Tetrahydrocannabinol (THC), the psychoactive compound in cannabis, is increasingly used recreationally, especially among young adults. Although often perceived as harmless, emerging evidence links THC to serious cardiovascular complications, including QTc prolongation, ventricular arrhythmias, and sudden cardiac arrest, even in individuals without underlying heart disease. CASE REPORT A 26-year-old woman with a history of chronic cannabis use was brought to the Emergency Department (ED) after having a sudden cardiac arrest. Her initial rhythm was ventricular fibrillation, and return of spontaneous circulation was achieved following advanced cardiac life support. An initial electrocardiogram revealed sinus tachycardia with a QTc interval of 483 ms, and a urine drug screen was positive for THC. Cardiac catheterization performed 4 weeks later revealed normal coronary arteries. Her left ventricular ejection fraction, initially reduced at 25-30%, had normalized by the time of catheterization. She sustained hypoxic-ischemic brain injury, requiring prolonged rehabilitation. CONCLUSIONS This case highlights the potential for cannabis use to induce life-threatening cardiac arrhythmias, including QTc prolongation, and ventricular fibrillation, even in young adults with no prior cardiovascular risk factors. Clinicians should maintain a high index of suspicion for cannabis-induced cardiotoxicity in similar presentations, particularly as cannabis use becomes more widespread.</p>","PeriodicalId":39064,"journal":{"name":"American Journal of Case Reports","volume":"26 ","pages":"e950077"},"PeriodicalIF":0.7000,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462534/pdf/","citationCount":"0","resultStr":"{\"title\":\"Cannabis-Induced Cardiac Arrest in a Young Adult: A Case Report.\",\"authors\":\"Sana Irshad, Parth Adrejiya, Mohammad Abubaker, Theophilus Adatsi, Oluchi Idenyi, Srikanth Maddika, Swathi Gorle, Abhishek Thandra, Srinivasa R Chennareddy\",\"doi\":\"10.12659/AJCR.950077\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>BACKGROUND Tetrahydrocannabinol (THC), the psychoactive compound in cannabis, is increasingly used recreationally, especially among young adults. Although often perceived as harmless, emerging evidence links THC to serious cardiovascular complications, including QTc prolongation, ventricular arrhythmias, and sudden cardiac arrest, even in individuals without underlying heart disease. CASE REPORT A 26-year-old woman with a history of chronic cannabis use was brought to the Emergency Department (ED) after having a sudden cardiac arrest. Her initial rhythm was ventricular fibrillation, and return of spontaneous circulation was achieved following advanced cardiac life support. An initial electrocardiogram revealed sinus tachycardia with a QTc interval of 483 ms, and a urine drug screen was positive for THC. Cardiac catheterization performed 4 weeks later revealed normal coronary arteries. Her left ventricular ejection fraction, initially reduced at 25-30%, had normalized by the time of catheterization. She sustained hypoxic-ischemic brain injury, requiring prolonged rehabilitation. CONCLUSIONS This case highlights the potential for cannabis use to induce life-threatening cardiac arrhythmias, including QTc prolongation, and ventricular fibrillation, even in young adults with no prior cardiovascular risk factors. Clinicians should maintain a high index of suspicion for cannabis-induced cardiotoxicity in similar presentations, particularly as cannabis use becomes more widespread.</p>\",\"PeriodicalId\":39064,\"journal\":{\"name\":\"American Journal of Case Reports\",\"volume\":\"26 \",\"pages\":\"e950077\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2025-09-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462534/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American Journal of Case Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.12659/AJCR.950077\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12659/AJCR.950077","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Cannabis-Induced Cardiac Arrest in a Young Adult: A Case Report.
BACKGROUND Tetrahydrocannabinol (THC), the psychoactive compound in cannabis, is increasingly used recreationally, especially among young adults. Although often perceived as harmless, emerging evidence links THC to serious cardiovascular complications, including QTc prolongation, ventricular arrhythmias, and sudden cardiac arrest, even in individuals without underlying heart disease. CASE REPORT A 26-year-old woman with a history of chronic cannabis use was brought to the Emergency Department (ED) after having a sudden cardiac arrest. Her initial rhythm was ventricular fibrillation, and return of spontaneous circulation was achieved following advanced cardiac life support. An initial electrocardiogram revealed sinus tachycardia with a QTc interval of 483 ms, and a urine drug screen was positive for THC. Cardiac catheterization performed 4 weeks later revealed normal coronary arteries. Her left ventricular ejection fraction, initially reduced at 25-30%, had normalized by the time of catheterization. She sustained hypoxic-ischemic brain injury, requiring prolonged rehabilitation. CONCLUSIONS This case highlights the potential for cannabis use to induce life-threatening cardiac arrhythmias, including QTc prolongation, and ventricular fibrillation, even in young adults with no prior cardiovascular risk factors. Clinicians should maintain a high index of suspicion for cannabis-induced cardiotoxicity in similar presentations, particularly as cannabis use becomes more widespread.
期刊介绍:
American Journal of Case Reports is an international, peer-reviewed scientific journal that publishes single and series case reports in all medical fields. American Journal of Case Reports is issued on a continuous basis as a primary electronic journal. Print copies of a single article or a set of articles can be ordered on demand.