Fazia Tadount, Guy Boivin, Yves Longtin, Patrice Savard, Matthew P Cheng, Hélène Decaluwe, Gaston De Serres, Élise Fortin, Caroline Quach
{"title":"COVID-19是否与成人后续上呼吸道感染风险增加有关？前瞻性队列研究。","authors":"Fazia Tadount, Guy Boivin, Yves Longtin, Patrice Savard, Matthew P Cheng, Hélène Decaluwe, Gaston De Serres, Élise Fortin, Caroline Quach","doi":"10.1093/ofid/ofaf544","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>In Autumn 2022, a surge in upper respiratory tract infections (URTIs) was observed worldwide. Individuals anecdotally reported increased URTIs in the months following their coronavirus disease 2019 (COVID-19). The objective was to assess if COVID-19 is associated with a higher incidence of URTI in adults in the following months.</p><p><strong>Methods: </strong><b>\"</b>RECOVER\" is a prospective cohort of health care workers (HCWs) from Montreal, Canada. HCWs completed biweekly surveys to report incident COVID-like symptoms. We included HCWs actively followed up for ≥90 days, between December 1, 2021, and December 31, 2022. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections were confirmed via reverse transcriptase polymerase chain reaction/antigenic testing. Non-COVID-19 URTI cases were defined as new onset of fever/sensation of fever, rhinitis, nasal congestion, sore throat/pharyngitis, sneezing, coughing, wheezing, difficulty breathing, increased respiratory secretions, or change in characteristics of chronic secretions, excluding symptoms within 48 hours of vaccination. Time-dependent Cox regression was used to assess the association between recent COVID-19 and URTI, adjusting for sex, age, workplace, household children <5 years, and asthma.</p><p><strong>Results: </strong>Among 320 HCWs (82.5% females; mean age, 42.4 years) followed for a median of 342 days, 152 (47.5%) participants tested positive for SARS-CoV-2. No significant difference in the incidence of URTI was observed following COVID-19 (hazard ratio, 1.03; 95% CI, 0.74-1.43; <i>P</i> = .87). However, having at least 1 child <5 years was associated with a 74% (95% CI, 20%-153%; <i>P</i> = .003) increase in the risk for URTI. Findings remained similar in sensitivity analysis.</p><p><strong>Conclusions: </strong>There was no association between COVID-19 and subsequent URTI. Other epidemiological, individual, and social factors could explain the increase in the incidence of URTI.</p>","PeriodicalId":19517,"journal":{"name":"Open Forum Infectious Diseases","volume":"12 9","pages":"ofaf544"},"PeriodicalIF":3.8000,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449730/pdf/","citationCount":"0","resultStr":"{\"title\":\"Is COVID-19 Associated With an Increased Risk of Subsequent Upper Respiratory Tract Infections in Adults? A Prospective Cohort Study.\",\"authors\":\"Fazia Tadount, Guy Boivin, Yves Longtin, Patrice Savard, Matthew P Cheng, Hélène Decaluwe, Gaston De Serres, Élise Fortin, Caroline Quach\",\"doi\":\"10.1093/ofid/ofaf544\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>In Autumn 2022, a surge in upper respiratory tract infections (URTIs) was observed worldwide. Individuals anecdotally reported increased URTIs in the months following their coronavirus disease 2019 (COVID-19). The objective was to assess if COVID-19 is associated with a higher incidence of URTI in adults in the following months.</p><p><strong>Methods: </strong><b>\\\"</b>RECOVER\\\" is a prospective cohort of health care workers (HCWs) from Montreal, Canada. HCWs completed biweekly surveys to report incident COVID-like symptoms. We included HCWs actively followed up for ≥90 days, between December 1, 2021, and December 31, 2022. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections were confirmed via reverse transcriptase polymerase chain reaction/antigenic testing. Non-COVID-19 URTI cases were defined as new onset of fever/sensation of fever, rhinitis, nasal congestion, sore throat/pharyngitis, sneezing, coughing, wheezing, difficulty breathing, increased respiratory secretions, or change in characteristics of chronic secretions, excluding symptoms within 48 hours of vaccination. Time-dependent Cox regression was used to assess the association between recent COVID-19 and URTI, adjusting for sex, age, workplace, household children <5 years, and asthma.</p><p><strong>Results: </strong>Among 320 HCWs (82.5% females; mean age, 42.4 years) followed for a median of 342 days, 152 (47.5%) participants tested positive for SARS-CoV-2. No significant difference in the incidence of URTI was observed following COVID-19 (hazard ratio, 1.03; 95% CI, 0.74-1.43; <i>P</i> = .87). However, having at least 1 child <5 years was associated with a 74% (95% CI, 20%-153%; <i>P</i> = .003) increase in the risk for URTI. Findings remained similar in sensitivity analysis.</p><p><strong>Conclusions: </strong>There was no association between COVID-19 and subsequent URTI. 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Is COVID-19 Associated With an Increased Risk of Subsequent Upper Respiratory Tract Infections in Adults? A Prospective Cohort Study.
Background: In Autumn 2022, a surge in upper respiratory tract infections (URTIs) was observed worldwide. Individuals anecdotally reported increased URTIs in the months following their coronavirus disease 2019 (COVID-19). The objective was to assess if COVID-19 is associated with a higher incidence of URTI in adults in the following months.
Methods: "RECOVER" is a prospective cohort of health care workers (HCWs) from Montreal, Canada. HCWs completed biweekly surveys to report incident COVID-like symptoms. We included HCWs actively followed up for ≥90 days, between December 1, 2021, and December 31, 2022. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections were confirmed via reverse transcriptase polymerase chain reaction/antigenic testing. Non-COVID-19 URTI cases were defined as new onset of fever/sensation of fever, rhinitis, nasal congestion, sore throat/pharyngitis, sneezing, coughing, wheezing, difficulty breathing, increased respiratory secretions, or change in characteristics of chronic secretions, excluding symptoms within 48 hours of vaccination. Time-dependent Cox regression was used to assess the association between recent COVID-19 and URTI, adjusting for sex, age, workplace, household children <5 years, and asthma.
Results: Among 320 HCWs (82.5% females; mean age, 42.4 years) followed for a median of 342 days, 152 (47.5%) participants tested positive for SARS-CoV-2. No significant difference in the incidence of URTI was observed following COVID-19 (hazard ratio, 1.03; 95% CI, 0.74-1.43; P = .87). However, having at least 1 child <5 years was associated with a 74% (95% CI, 20%-153%; P = .003) increase in the risk for URTI. Findings remained similar in sensitivity analysis.
Conclusions: There was no association between COVID-19 and subsequent URTI. Other epidemiological, individual, and social factors could explain the increase in the incidence of URTI.
期刊介绍：
Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.
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