胰十二指肠切除术后胃电生理、症状和生活质量的长期评价。

IF 2.4 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Hpb Pub Date : 2025-09-05 DOI:10.1016/j.hpb.2025.09.003

Tim Hsu-Han Wang, Chris Varghese, Stefan Calder, Armen Gharibans, Gabriel Schamberg, Adam Bartlett, Sanket Srinivasa, Greg O'Grady

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引用次数: 0

摘要

背景：胰十二指肠切除术（PD）通常用于胰腺和胆道恶性肿瘤。术后胃功能障碍是常见的，其潜在的病理生理机制尚不清楚。本研究旨在评估PD后的胃电生理、症状和生活质量（QoL），采用新型无创胃Alimetry测图系统。方法：招募2017年至2022年来自奥克兰的PD患者。采用胃Alimetry®（Alimetry，新西兰），包括可拉伸可穿戴阵列（8×8电极）和经过验证的用于症状记录的应用程序。餐前记录30分钟，餐后记录4小时。收集的数据包括主胃频率、bmi调整振幅、胃节律指数、用餐反应、症状和生活质量问卷（PAGI-QOL、EQ-5D-5L）。将数据与匹配的健康对照进行比较。进行Pearson相关分析。结果：共纳入19例患者和19例健康对照。8/19患者出现中重度症状和生活质量（42%），8/19患者出现至少一项电生理参数异常（42%），但不相关（p=0.43）。PAGI-QOL和EQ-5D-5L与对照组有显著差异(p结论：PD后中重度上消化道症状较为常见。虽然胃电生理改变很常见，但其他因素可能与长期生活质量更相关。值得注意的是，短期关联尚未得到调查。

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Long-term evaluation of gastric electrophysiology, symptoms and quality of life after pancreaticoduodenectomy.

Background: Pancreaticoduodenectomy (PD) is typically performed for pancreatic and biliary malignancies. Post-operative gastric dysfunction is common and the underlying pathophysiology is still poorly understood. This study aimed to evaluate the gastric electrophysiology, symptoms and quality of life (QoL) following PD, using the novel non-invasive Gastric Alimetry mapping system.

Methods: PD patients from Auckland between 2017 and 2022 were recruited. Gastric Alimetry® (Alimetry, New Zealand) was employed, comprising a stretchable wearable array (8×8 electrodes) and a validated app for symptom logging. A 30-min pre-prandial and a 4-hour post-prandial recording was performed. Data collected includes Principal Gastric Frequency, BMI-adjusted amplitude, Gastric Alimetry Rhythm Index, meal response, symptoms and QoL questionnaires (PAGI-QOL, EQ-5D-5L). Data was compared to matched healthy controls. Pearson's correlation analysis was performed.

Results: 19 patients and 19 healthy controls were recruited. Moderate to severe symptoms and QoL were found in 8/19 (42 %) and at least one abnormal electrophysiology parameter in 8/19 (42 %), albeit uncorrelated (p=0.43). Significant differences were found in PAGI-QOL and EQ-5D-5L with controls (p<0.01).

Conclusion: Moderate to severe upper GI symptoms are common after PD. Although altered gastric electrophysiology is common, other factors are likely more relevant to long-term QoL. Notably, short term associations remain uninvestigated.

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来源期刊

Hpb GASTROENTEROLOGY & HEPATOLOGY-SURGERY

CiteScore

5.60

自引率

3.40%

发文量

244

审稿时长

57 days

期刊介绍： HPB is an international forum for clinical, scientific and educational communication. Twelve issues a year bring the reader leading articles, expert reviews, original articles, images, editorials, and reader correspondence encompassing all aspects of benign and malignant hepatobiliary disease and its management. HPB features relevant aspects of clinical and translational research and practice. Specific areas of interest include HPB diseases encountered globally by clinical practitioners in this specialist field of gastrointestinal surgery. The journal addresses the challenges faced in the management of cancer involving the liver, biliary system and pancreas. While surgical oncology represents a large part of HPB practice, submission of manuscripts relating to liver and pancreas transplantation, the treatment of benign conditions such as acute and chronic pancreatitis, and those relating to hepatobiliary infection and inflammation are also welcomed. There will be a focus on developing a multidisciplinary approach to diagnosis and treatment with endoscopic and laparoscopic approaches, radiological interventions and surgical techniques being strongly represented. HPB welcomes submission of manuscripts in all these areas and in scientific focused research that has clear clinical relevance to HPB surgical practice. HPB aims to help its readers - surgeons, physicians, radiologists and basic scientists - to develop their knowledge and practice. HPB will be of interest to specialists involved in the management of hepatobiliary and pancreatic disease however will also inform those working in related fields. Abstracted and Indexed in: MEDLINE® EMBASE PubMed Science Citation Index Expanded Academic Search (EBSCO) HPB is owned by the International Hepato-Pancreato-Biliary Association (IHPBA) and is also the official Journal of the American Hepato-Pancreato-Biliary Association (AHPBA), the Asian-Pacific Hepato Pancreatic Biliary Association (A-PHPBA) and the European-African Hepato-Pancreatic Biliary Association (E-AHPBA).