Xiaoyu Liu, Yinzhong Wang, Caihua Xu, Yixiang Li, Junqiang Lei
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引用次数: 0
摘要
目的：本研究旨在评价T1ρ松弛在鉴别肝纤维化（LF）患者中的诊断价值。方法：使用PubMed、EMBASE、Cochrane和Web of Science数据库进行系统综述，以确定评估T1ρ用于LF诊断的研究。结果：纳入11项研究，涉及792例患者。肝硬化患者的T1ρ值显著高于正常肝脏[加权平均差值（WMD）： 6.69, P < 0.001]，纤维化患者的T1ρ值显著高于正常肝脏（WMD: 7.17, P = 0.006）。Child-Pugh A、B、C级患者的T1ρ值明显高于正常肝脏（P < 0.001）。f1 ~ f3期肝组织T1ρ值与正常肝脏比较差异无统计学意义（P = 0.18）， F4期肝组织T1ρ值与正常肝脏比较差异有统计学意义（WMD: 10.48, P = 0.02）。结论：T1ρ松弛可区分高级别LF与正常肝组织。临床意义：T1ρ作为一种无创成像技术，在LF的诊断和随访以及优化慢性肝病的评估和管理方面具有潜在的应用价值。
Magnetic resonance T1ρ relaxation in patients with liver fibrosis: a systematic review and meta-analysis.
Purpose: This study aimed to evaluate the diagnostic performance of T1ρ relaxation in distinguishing patients with liver fibrosis (LF) from those without.
Methods: A systematic review was conducted using PubMed, EMBASE, Cochrane, and Web of Science databases up to February 2025 to identify studies assessing T1ρ for LF diagnosis.
Results: Eleven studies involving 792 patients were included. T1ρ values were significantly higher in cirrhotic versus normal livers [weighted mean difference (WMD): 6.69, P < 0.001], and in fibrotic versus normal livers (WMD: 7.17, P = 0.006). Patients with Child-Pugh classes A, B, and C showed significantly higher T1ρ values compared with normal liver (P < 0.001). T1ρ values in LF stages F1-F3 were not significantly different from normal liver (P = 0.18), but stage F4 showed significant differences (WMD: 10.48, P = 0.02).
Conclusion: T1ρ relaxation differentiates high-grade LF from normal liver tissue.
Clinical significance: As a non-invasive imaging technique, T1ρ shows potential for use in the diagnosis and follow-up of LF and to optimize the assessment and management of chronic liver disease.
期刊介绍：
Diagnostic and Interventional Radiology (Diagn Interv Radiol) is the open access, online-only official publication of Turkish Society of Radiology. It is published bimonthly and the journal’s publication language is English.
The journal is a medium for original articles, reviews, pictorial essays, technical notes related to all fields of diagnostic and interventional radiology.
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