Fuzhen Yuan, Zhenhua Huang, Eryao Zhang, Dingye Yao, Junsheng Sun
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Anti-MDA5 Positive Dermatomyositis Overlapping with Rheumatoid Arthritis: A Case Report.
We report a rare case of overlap syndrome between anti-MDA5-positive dermatomyositis (DM) and rheumatoid arthritis (RA) in a 65-year-old woman. Initially diagnosed with RA, the patient later developed characteristic DM manifestations including characteristic DM rash, generalized weakness, poor appetite, and unintentional weight loss. Laboratory findings revealed elevated muscle enzymes, positive anti-melanoma differentiation-associated gene 5 (MDA5) antibody and anti-Ro52 antibodies, and increased anti-citrullinated protein antibodies. The patient showed significant improvement following combination therapy with prednisone and mycophenolate mofetil, highlighting the importance of early recognition and appropriate management of this rare overlap syndrome.
期刊介绍：
Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal.
Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest.
The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care.
All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.
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