Qi-Huang Zheng, Min Wang, Barbara E Glick-Wilson, Chase A Arkins, Eric R Klueppelberg, Scott E Snyder, Michael L Schulte
{"title":"两种不同自动化放射化学系统上[18F]场效应管合成的优化与比较。","authors":"Qi-Huang Zheng, Min Wang, Barbara E Glick-Wilson, Chase A Arkins, Eric R Klueppelberg, Scott E Snyder, Michael L Schulte","doi":"10.62347/SPOE8395","DOIUrl":null,"url":null,"abstract":"<p><p><i>O</i>-(2-[<sup>18</sup>F]Fluoroethyl)- <i><sub>L</sub></i> -tyrosine ([<sup>18</sup>F]FET) is a promising amino acid PET tracer for assessment of malignant brain tumors. Herein, we report optimized production of [<sup>18</sup>F]FET for clinical use on two commercial radiochemistry systems: Sofie ELIXYS and GE FASTlab 2. While the Sofie ELIXYS procedure requires high performance liquid chromatography (HPLC) purification, the GE FASTlab 2 method uses solid-phase extraction (SPE) purification. In both cases, [<sup>18</sup>F]FET met release specifications for clinical investigation laid out in the United States Pharmacopeia (USP) and/or European Pharmacopeia (Ph. Eur.). The radiochemical yield of [<sup>18</sup>F]FET was 35-55% and 30-55% decay corrected to start of synthesis (SOS) for Sofie ELIXYS and GE FASTlab 2, respectively. The overall synthesis time was 75-85 and 70-80 min from SOS for Sofie ELIXYS and GE FASTlab 2, respectively. The radiochemical purity was > 99%, and the molar activity (A<sub>m</sub>) was 340-464 GBq/µmol at end of synthesis (EOS).</p>","PeriodicalId":7572,"journal":{"name":"American journal of nuclear medicine and molecular imaging","volume":"15 4","pages":"158-166"},"PeriodicalIF":1.8000,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444399/pdf/","citationCount":"0","resultStr":"{\"title\":\"Optimization and comparison of [<sup>18</sup>F]FET synthesis on two distinct automated radiochemistry systems.\",\"authors\":\"Qi-Huang Zheng, Min Wang, Barbara E Glick-Wilson, Chase A Arkins, Eric R Klueppelberg, Scott E Snyder, Michael L Schulte\",\"doi\":\"10.62347/SPOE8395\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>O</i>-(2-[<sup>18</sup>F]Fluoroethyl)- <i><sub>L</sub></i> -tyrosine ([<sup>18</sup>F]FET) is a promising amino acid PET tracer for assessment of malignant brain tumors. Herein, we report optimized production of [<sup>18</sup>F]FET for clinical use on two commercial radiochemistry systems: Sofie ELIXYS and GE FASTlab 2. While the Sofie ELIXYS procedure requires high performance liquid chromatography (HPLC) purification, the GE FASTlab 2 method uses solid-phase extraction (SPE) purification. In both cases, [<sup>18</sup>F]FET met release specifications for clinical investigation laid out in the United States Pharmacopeia (USP) and/or European Pharmacopeia (Ph. Eur.). The radiochemical yield of [<sup>18</sup>F]FET was 35-55% and 30-55% decay corrected to start of synthesis (SOS) for Sofie ELIXYS and GE FASTlab 2, respectively. The overall synthesis time was 75-85 and 70-80 min from SOS for Sofie ELIXYS and GE FASTlab 2, respectively. The radiochemical purity was > 99%, and the molar activity (A<sub>m</sub>) was 340-464 GBq/µmol at end of synthesis (EOS).</p>\",\"PeriodicalId\":7572,\"journal\":{\"name\":\"American journal of nuclear medicine and molecular imaging\",\"volume\":\"15 4\",\"pages\":\"158-166\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2025-08-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444399/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American journal of nuclear medicine and molecular imaging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.62347/SPOE8395\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of nuclear medicine and molecular imaging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.62347/SPOE8395","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Optimization and comparison of [18F]FET synthesis on two distinct automated radiochemistry systems.
O-(2-[18F]Fluoroethyl)- L -tyrosine ([18F]FET) is a promising amino acid PET tracer for assessment of malignant brain tumors. Herein, we report optimized production of [18F]FET for clinical use on two commercial radiochemistry systems: Sofie ELIXYS and GE FASTlab 2. While the Sofie ELIXYS procedure requires high performance liquid chromatography (HPLC) purification, the GE FASTlab 2 method uses solid-phase extraction (SPE) purification. In both cases, [18F]FET met release specifications for clinical investigation laid out in the United States Pharmacopeia (USP) and/or European Pharmacopeia (Ph. Eur.). The radiochemical yield of [18F]FET was 35-55% and 30-55% decay corrected to start of synthesis (SOS) for Sofie ELIXYS and GE FASTlab 2, respectively. The overall synthesis time was 75-85 and 70-80 min from SOS for Sofie ELIXYS and GE FASTlab 2, respectively. The radiochemical purity was > 99%, and the molar activity (Am) was 340-464 GBq/µmol at end of synthesis (EOS).
期刊介绍：
The scope of AJNMMI encompasses all areas of molecular imaging, including but not limited to: positron emission tomography (PET), single-photon emission computed tomography (SPECT), molecular magnetic resonance imaging, magnetic resonance spectroscopy, optical bioluminescence, optical fluorescence, targeted ultrasound, photoacoustic imaging, etc. AJNMMI welcomes original and review articles on both clinical investigation and preclinical research. Occasionally, special topic issues, short communications, editorials, and invited perspectives will also be published. Manuscripts, including figures and tables, must be original and not under consideration by another journal.
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