Bruna Aparecida Melo Batista, Matheus Aragão Dias Firmino, Paula Alexandre de Freitas, Morgana Pinheiro Sousa, Ana Carolina Marinho Ferreira, André Pires Cortez, Wladiana Oliveira Matos, Francisco Luan Fonsêca da Silva, Carla Soraya Costa Maia
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Copper/zinc ratio and erythrocyte superoxide dismutase in patients with thyroid nodules.
The aim of this study was to evaluate biomarkers of zinc and copper status in patients with thyroid nodules. A cross-sectional study of 122 participants with thyroid nodules, diagnosed with cytological examinations (Nodule group) and 72 healthy subjects (Control group) were performed. Anthropometric data were collected; plasma concentrations of zinc and copper were analyzed by flame atomic absorption spectrophotometry and erythrocyte superoxide dismutase (SOD) activity was determined in an automatic biochemical analyzer using spectrophotometry to quantify the enzyme activity. The content of Zn in plasma was lower in the Nodule group than in the Control group, but plasma copper, copper/zinc ratio and erythrocyte SOD activity were higher in the Nodule group (p < 0.001). The levels of Cu and Zn are in the normal range, but the ratio Cu/Zn is altered in nodules group. Thyroid nodule patients exhibited changes in zinc and copper biomarker status compared to healthy individuals. The Cu/Zn ratio is a much more sensitive parameter for evaluating mineral metabolism in thyroid diseases.
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BioMetals is the only established journal to feature the important role of metal ions in chemistry, biology, biochemistry, environmental science, and medicine. BioMetals is an international, multidisciplinary journal singularly devoted to the rapid publication of the fundamental advances of both basic and applied research in this field. BioMetals offers a forum for innovative research and clinical results on the structure and function of:
- metal ions
- metal chelates,
- siderophores,
- metal-containing proteins
- biominerals in all biosystems.
- BioMetals rapidly publishes original articles and reviews.
BioMetals is a journal for metals researchers who practice in medicine, biochemistry, pharmacology, toxicology, microbiology, cell biology, chemistry, and plant physiology who are based academic, industrial and government laboratories.
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