{"title":"含吡唑吡啶配体的马脾载铁蛋白包封有机钌配合物对细胞毒性和抗菌素耐药性的调节。","authors":"Arangasamy Mounica, Balasubramani Saveetha, Arumugam Madan Kumar, Mani Ganeshpandian","doi":"10.1002/asia.202500781","DOIUrl":null,"url":null,"abstract":"<p><p>Horse spleen apoferritin is a highly efficient nanocarrier for encapsulating and delivering metallodrugs, resulting in enhanced stability and therapeutic effectiveness. Herein, Horse spleen apoferritin nanocage(Aftn) is used to encapsulate the model organoruthenium complex bearing a pyrazolyl-pyridine ligand (Ru(bpy)) via a pH-induced disassembly/reassembly method to obtain Ru(bpy)-loaded nanoformulation (Ru-Aftn). This nanoformulation exhibits sustained release of the loaded complex over a period of 6 days with minimal burst release. Ru-Aftn also displays prominent cytotoxicity with better selectivity than the non-encapsulated Ru(bpy) complex against MCF-7 breast cancer cells. AO/EB staining assay revealed that the non-encapsulated complex induced late apoptosis before loading, whereas early apoptosis occurred after being loaded into Aftn. These results support that Aftn can act as a promising carrier for metallodrugs in modulating their molecular mechanism. Nevertheless, it fails to improve the antimicrobial activity of Ru(bpy) when tested against ancomycin-resistant Enterococcus (VRE) strains.</p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e00781"},"PeriodicalIF":3.3000,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Horse Spleen Apoferritin-Encapsulated Organoruthenium Complex Bearing Pyrazolyl-Pyridine Ligand for Cytotoxic and Antimicrobial Resistance Modulations.\",\"authors\":\"Arangasamy Mounica, Balasubramani Saveetha, Arumugam Madan Kumar, Mani Ganeshpandian\",\"doi\":\"10.1002/asia.202500781\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Horse spleen apoferritin is a highly efficient nanocarrier for encapsulating and delivering metallodrugs, resulting in enhanced stability and therapeutic effectiveness. Herein, Horse spleen apoferritin nanocage(Aftn) is used to encapsulate the model organoruthenium complex bearing a pyrazolyl-pyridine ligand (Ru(bpy)) via a pH-induced disassembly/reassembly method to obtain Ru(bpy)-loaded nanoformulation (Ru-Aftn). This nanoformulation exhibits sustained release of the loaded complex over a period of 6 days with minimal burst release. Ru-Aftn also displays prominent cytotoxicity with better selectivity than the non-encapsulated Ru(bpy) complex against MCF-7 breast cancer cells. AO/EB staining assay revealed that the non-encapsulated complex induced late apoptosis before loading, whereas early apoptosis occurred after being loaded into Aftn. These results support that Aftn can act as a promising carrier for metallodrugs in modulating their molecular mechanism. Nevertheless, it fails to improve the antimicrobial activity of Ru(bpy) when tested against ancomycin-resistant Enterococcus (VRE) strains.</p>\",\"PeriodicalId\":145,\"journal\":{\"name\":\"Chemistry - An Asian Journal\",\"volume\":\" \",\"pages\":\"e00781\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-09-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemistry - An Asian Journal\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://doi.org/10.1002/asia.202500781\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry - An Asian Journal","FirstCategoryId":"1","ListUrlMain":"https://doi.org/10.1002/asia.202500781","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Horse Spleen Apoferritin-Encapsulated Organoruthenium Complex Bearing Pyrazolyl-Pyridine Ligand for Cytotoxic and Antimicrobial Resistance Modulations.
Horse spleen apoferritin is a highly efficient nanocarrier for encapsulating and delivering metallodrugs, resulting in enhanced stability and therapeutic effectiveness. Herein, Horse spleen apoferritin nanocage(Aftn) is used to encapsulate the model organoruthenium complex bearing a pyrazolyl-pyridine ligand (Ru(bpy)) via a pH-induced disassembly/reassembly method to obtain Ru(bpy)-loaded nanoformulation (Ru-Aftn). This nanoformulation exhibits sustained release of the loaded complex over a period of 6 days with minimal burst release. Ru-Aftn also displays prominent cytotoxicity with better selectivity than the non-encapsulated Ru(bpy) complex against MCF-7 breast cancer cells. AO/EB staining assay revealed that the non-encapsulated complex induced late apoptosis before loading, whereas early apoptosis occurred after being loaded into Aftn. These results support that Aftn can act as a promising carrier for metallodrugs in modulating their molecular mechanism. Nevertheless, it fails to improve the antimicrobial activity of Ru(bpy) when tested against ancomycin-resistant Enterococcus (VRE) strains.
期刊介绍：
Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics.
Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews.
A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal.
Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).
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