确定高血压发病和消退的敏感期及其亚型

IF 2.5 3区 医学 Q2 PERIPHERAL VASCULAR DISEASE
Xin Meng, Chaonan Gao, Jingfan Xiong, QianJin Qi, Wei Liu, Yongxi Xue, Hongbo Dong, Jie Mi, Yinkun Yan
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引用次数: 0

摘要

高血压是一个全球性的重大公共卫生问题,然而在整个生命周期中,血压(BP)类别和高血压亚型的患病率和转变模式的年龄相关变化仍不清楚。该动态队列研究纳入了1989-2015年中国健康与营养调查中年龄在3-80岁的22 858名参与者。根据基线年龄,以10年为间隔将参与者分为8个亚队列,分别为3-10岁、11-20岁、21-30岁、31-40岁、41-50岁、51-60岁、61-70岁和71-80岁。研究发现,对于血压正常的参与者,在10年的随访期内,成年期发生高血压的概率随着年龄的增长而增加,41-50岁开始发生收缩期高血压的概率超过舒张期高血压的概率。相比之下,对于高血压患者,在成年期血压恢复正常的概率随着年龄的增长而降低,其中11-20岁的血压恢复正常的概率最高。维持高血压的可能性显示出与年龄相关的不同趋势。这些发现在协变量调整的其他分析中基本保持不变,被限制为20年的随访或按性别分层。综上所述,血压正常的个体在成年后期更容易发生高血压,而高血压患者在青春期更容易恢复到正常血压。高血压患病率的年龄相关变化和生命周期内的动态转变强调了制定适合年龄的预防和干预策略的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Identify Sensitive Periods for Onset and Resolution of Hypertension and Its Subtypes Over the Lifespan

Identify Sensitive Periods for Onset and Resolution of Hypertension and Its Subtypes Over the Lifespan

Hypertension represents a significant public health issue globally, yet the age-related changes in prevalence and transition patterns of blood pressure (BP) categories and hypertension subtypes throughout the lifespan remain unclear. This dynamic cohort study included 22 858 participants aged 3–80 years from the China Health and Nutrition Survey 1989–2015. Participants were categorized into eight sub-cohorts based on baseline age in 10-year intervals, i.e., 3–10, 11–20, 21–30, 31–40, 41–50, 51–60, 61–70, and 71–80 years. The study found that for participants with normal BP, the probabilities of developing hypertension over a 10-year follow-up period increased with age during adulthood, with the probabilities of developing systolic hypertension surpassing those of diastolic hypertension beginning at 41–50 years. In comparison, for participants with hypertension, the probabilities of reverting to normal BP generally decreased with age during adulthood, with those aged 11–20 years having the highest probabilities. The probabilities of maintaining hypertension showed contrasting age-related trends. These findings remained largely unchanged in additional analyses of adjustment for covariates, being restricted to a 20-year follow-up or being stratified by sex. In conclusion, individuals with normal BP are more likely to develop hypertension in late adulthood, whereas those with hypertension are more likely to revert to normal BP during adolescence. The age-related changes in prevalence and dynamic transition of hypertension over the lifespan underscore the necessity for developing age-appropriate prevention and intervention strategies.

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来源期刊
Journal of Clinical Hypertension
Journal of Clinical Hypertension PERIPHERAL VASCULAR DISEASE-
CiteScore
5.80
自引率
7.10%
发文量
191
审稿时长
4-8 weeks
期刊介绍: The Journal of Clinical Hypertension is a peer-reviewed, monthly publication that serves internists, cardiologists, nephrologists, endocrinologists, hypertension specialists, primary care practitioners, pharmacists and all professionals interested in hypertension by providing objective, up-to-date information and practical recommendations on the full range of clinical aspects of hypertension. Commentaries and columns by experts in the field provide further insights into our original research articles as well as on major articles published elsewhere. Major guidelines for the management of hypertension are also an important feature of the Journal. Through its partnership with the World Hypertension League, JCH will include a new focus on hypertension and public health, including major policy issues, that features research and reviews related to disease characteristics and management at the population level.
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