影响肌萎缩侧索硬化症患者活动能力丧失的因素：一项回顾性队列研究

IF 2.1 Q2 MEDICINE, GENERAL & INTERNAL

Health Science Reports Pub Date : 2025-09-22 DOI:10.1002/hsr2.71282

Takahiro Miyashita, Eiki Tsushima, Hirofumi Ogihara

{"title":"影响肌萎缩侧索硬化症患者活动能力丧失的因素：一项回顾性队列研究","authors":"Takahiro Miyashita, Eiki Tsushima, Hirofumi Ogihara","doi":"10.1002/hsr2.71282","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background and Aims</h3>\n \n <p>Loss of ambulation in patients with amyotrophic lateral sclerosis (ALS) reduces their social participation and quality of life. Moreover, loss of ambulation is one of the biggest obstacles for patients and their caretakers. However, prognostic factors for loss of ambulation in patients with ALS have not been clarified. This study aimed to investigate the time to loss of ambulation in Japanese patients with ALS and to identify factors associated with loss of ambulation.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Overall, 62 patients with ALS were enrolled. Survey items included patient background, pre-existing medical conditions, and laboratory data. Cox proportional hazards regression analysis was performed with the time to loss of ambulation as the dependent variable and age at onset, sex, onset type, duration to diagnosis, ALS severity, diabetes mellitus (DM), and %forced vital capacity (%FVC) as independent variables.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The median time to loss of ambulation for all ALS patients was 16.5 (10.0–31.3) months. Cox regression analysis revealed a significant association between duration to diagnosis (HR: 0.94, 95% CI: 0.91–0.97, <i>p</i> < 0.001) and DM (HR: 3.30, 95% CI: 1.62–6.69, <i>p</i> < 0.001).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Time to diagnosis and history of diabetes are important factors associated with the time to loss of ambulation in patients with ALS.</p>\n </section>\n \n <section>\n \n <h3> Trial Registration</h3>\n \n <p>Retrospectively registered.</p>\n </section>\n </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"8 9","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.71282","citationCount":"0","resultStr":"{\"title\":\"Factors Influencing the Loss of Ambulation in Patients With Amyotrophic Lateral Sclerosis: A Retrospective Cohort Study\",\"authors\":\"Takahiro Miyashita, Eiki Tsushima, Hirofumi Ogihara\",\"doi\":\"10.1002/hsr2.71282\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background and Aims</h3>\\n \\n <p>Loss of ambulation in patients with amyotrophic lateral sclerosis (ALS) reduces their social participation and quality of life. Moreover, loss of ambulation is one of the biggest obstacles for patients and their caretakers. However, prognostic factors for loss of ambulation in patients with ALS have not been clarified. This study aimed to investigate the time to loss of ambulation in Japanese patients with ALS and to identify factors associated with loss of ambulation.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Overall, 62 patients with ALS were enrolled. Survey items included patient background, pre-existing medical conditions, and laboratory data. Cox proportional hazards regression analysis was performed with the time to loss of ambulation as the dependent variable and age at onset, sex, onset type, duration to diagnosis, ALS severity, diabetes mellitus (DM), and %forced vital capacity (%FVC) as independent variables.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>The median time to loss of ambulation for all ALS patients was 16.5 (10.0–31.3) months. Cox regression analysis revealed a significant association between duration to diagnosis (HR: 0.94, 95% CI: 0.91–0.97, <i>p</i> < 0.001) and DM (HR: 3.30, 95% CI: 1.62–6.69, <i>p</i> < 0.001).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>Time to diagnosis and history of diabetes are important factors associated with the time to loss of ambulation in patients with ALS.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Trial Registration</h3>\\n \\n <p>Retrospectively registered.</p>\\n </section>\\n </div>\",\"PeriodicalId\":36518,\"journal\":{\"name\":\"Health Science Reports\",\"volume\":\"8 9\",\"pages\":\"\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-09-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.71282\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Health Science Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/hsr2.71282\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Health Science Reports","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/hsr2.71282","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

摘要

背景和目的肌萎缩性侧索硬化症（ALS）患者的活动能力丧失降低了他们的社会参与和生活质量。此外，丧失行动能力是患者及其护理人员面临的最大障碍之一。然而，ALS患者活动能力丧失的预后因素尚未明确。本研究旨在调查日本ALS患者丧失行走能力的时间，并确定与行走能力丧失相关的因素。方法共纳入62例ALS患者。调查项目包括患者背景、既往医疗状况和实验室数据。以丧失活动能力时间为因变量，以发病年龄、性别、发病类型、发病时间、ALS严重程度、糖尿病（DM）和用力肺活量（%FVC）为自变量，进行Cox比例风险回归分析。结果所有ALS患者失去活动能力的中位时间为16.5（10.0-31.3）个月。Cox回归分析显示，诊断前持续时间（HR: 0.94, 95% CI: 0.91-0.97, p < 0.001）与DM （HR: 3.30, 95% CI: 1.62-6.69, p < 0.001）之间存在显著相关性。结论诊断时间和糖尿病史是影响ALS患者丧失活动时间的重要因素。试验注册回顾性注册。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Factors Influencing the Loss of Ambulation in Patients With Amyotrophic Lateral Sclerosis: A Retrospective Cohort Study

查看原文本刊更多论文

Factors Influencing the Loss of Ambulation in Patients With Amyotrophic Lateral Sclerosis: A Retrospective Cohort Study

Background and Aims

Loss of ambulation in patients with amyotrophic lateral sclerosis (ALS) reduces their social participation and quality of life. Moreover, loss of ambulation is one of the biggest obstacles for patients and their caretakers. However, prognostic factors for loss of ambulation in patients with ALS have not been clarified. This study aimed to investigate the time to loss of ambulation in Japanese patients with ALS and to identify factors associated with loss of ambulation.

Methods

Overall, 62 patients with ALS were enrolled. Survey items included patient background, pre-existing medical conditions, and laboratory data. Cox proportional hazards regression analysis was performed with the time to loss of ambulation as the dependent variable and age at onset, sex, onset type, duration to diagnosis, ALS severity, diabetes mellitus (DM), and %forced vital capacity (%FVC) as independent variables.

Results

The median time to loss of ambulation for all ALS patients was 16.5 (10.0–31.3) months. Cox regression analysis revealed a significant association between duration to diagnosis (HR: 0.94, 95% CI: 0.91–0.97, p < 0.001) and DM (HR: 3.30, 95% CI: 1.62–6.69, p < 0.001).