Sadia Latif, Zulfiqar Ali Raza, Mina Hafeez, Tazeen Riaz, Rashid Masood
{"title":"负载α -生育酚的牛血清白蛋白纳米结构的合成及其在纤维素织物上的浸渍","authors":"Sadia Latif, Zulfiqar Ali Raza, Mina Hafeez, Tazeen Riaz, Rashid Masood","doi":"10.1007/s10570-025-06673-x","DOIUrl":null,"url":null,"abstract":"<div><p>This study employed the desolvation method to encapsulate alpha-tocopherol encapsulation in the bovine serum albumin (BSA) nanoparticles (NPs). Alpha-tocopherol is an effective antioxidant; however, it is poorly stable in oxidizing environments. It was expected that the stability of alpha-tocopherol could be improved when capped in suitable micellar structures. BSA is a bio-compatible, biodegradable, and non-toxic material and can be used to encapsulate alpha-tocopherol to increase its stability and acquire a controlled release. The BSA-encapsulated alpha-tocopherol-loaded NPs were applied to cellulose fabric. The BSA nanoparticles (BNPs) and alpha-tocopherol loaded-BNPs were characterized using UV–vis spectrophotometry, dynamic light scattering, differential scanning calorimetry, Fourier-transform infrared and stability analyses. The results demonstrated the spherical morphology of NPs, as observed under the SEM machine. The unloaded BNPs expressed the <i>z</i>-average size of 92 ± 5 nm, which became 95 ± 5–194 ± 5 depending on alpha-tocopherol loading. The FTIR analysis confirmed the successful impregnation of alpha-tocopherol in the BNPs. The alpha-tocopherol-loaded BNPs expressed up to 68 ± 4% release at the pH of 7.4. The alpha-tocopherol encapsulated in BNPs in the presence of rhamnolipid surfactant expressed in a controlled release in the buffer media. The tensile strength and elongation at the break values of untreated fabric were observed as 63 ± 3 MPa and 18 ± 1%, which increased to 92 ± 5 MPa and 25 ± 1%, respectively, on treatment with alpha-tocopherol-loaded BNPs at 200 mg/g. The alpha-tocopherol-loaded BNP-treated cellulose fabric exhibited more finish release (66 ± 3%) at 7.4 whereas limited (23 ± 2–25 ± 2%) in the pH range 5.4–6.4, i.e., the finish stability and release were pH-sensitive. Overall, the study focused on the development of sustainable drug delivery systems using renewable materials, like BSA as the shell matrix, alpha-tocopherol as an antioxidant, rhamnolipid as biosurfactant, cellulose as the substrate and citric acid as an eco-friendly cross-linker. The hence-produced cellulose fabric treated with alpha-tocopherol-loaded BSA inclusions expressed exceptional antioxidant activity and comfort properties. It thus can offer numerous benefits in the healthcare sector in skin care, eczema, and cosmetotextiles.</p></div>","PeriodicalId":511,"journal":{"name":"Cellulose","volume":"32 14","pages":"8547 - 8565"},"PeriodicalIF":4.8000,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis of alpha-tocopherol-loaded bovine serum albumin nanostructures and their impregnation on cellulose fabric for potential biomedical application\",\"authors\":\"Sadia Latif, Zulfiqar Ali Raza, Mina Hafeez, Tazeen Riaz, Rashid Masood\",\"doi\":\"10.1007/s10570-025-06673-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>This study employed the desolvation method to encapsulate alpha-tocopherol encapsulation in the bovine serum albumin (BSA) nanoparticles (NPs). Alpha-tocopherol is an effective antioxidant; however, it is poorly stable in oxidizing environments. It was expected that the stability of alpha-tocopherol could be improved when capped in suitable micellar structures. BSA is a bio-compatible, biodegradable, and non-toxic material and can be used to encapsulate alpha-tocopherol to increase its stability and acquire a controlled release. The BSA-encapsulated alpha-tocopherol-loaded NPs were applied to cellulose fabric. The BSA nanoparticles (BNPs) and alpha-tocopherol loaded-BNPs were characterized using UV–vis spectrophotometry, dynamic light scattering, differential scanning calorimetry, Fourier-transform infrared and stability analyses. The results demonstrated the spherical morphology of NPs, as observed under the SEM machine. The unloaded BNPs expressed the <i>z</i>-average size of 92 ± 5 nm, which became 95 ± 5–194 ± 5 depending on alpha-tocopherol loading. The FTIR analysis confirmed the successful impregnation of alpha-tocopherol in the BNPs. The alpha-tocopherol-loaded BNPs expressed up to 68 ± 4% release at the pH of 7.4. The alpha-tocopherol encapsulated in BNPs in the presence of rhamnolipid surfactant expressed in a controlled release in the buffer media. The tensile strength and elongation at the break values of untreated fabric were observed as 63 ± 3 MPa and 18 ± 1%, which increased to 92 ± 5 MPa and 25 ± 1%, respectively, on treatment with alpha-tocopherol-loaded BNPs at 200 mg/g. The alpha-tocopherol-loaded BNP-treated cellulose fabric exhibited more finish release (66 ± 3%) at 7.4 whereas limited (23 ± 2–25 ± 2%) in the pH range 5.4–6.4, i.e., the finish stability and release were pH-sensitive. Overall, the study focused on the development of sustainable drug delivery systems using renewable materials, like BSA as the shell matrix, alpha-tocopherol as an antioxidant, rhamnolipid as biosurfactant, cellulose as the substrate and citric acid as an eco-friendly cross-linker. The hence-produced cellulose fabric treated with alpha-tocopherol-loaded BSA inclusions expressed exceptional antioxidant activity and comfort properties. It thus can offer numerous benefits in the healthcare sector in skin care, eczema, and cosmetotextiles.</p></div>\",\"PeriodicalId\":511,\"journal\":{\"name\":\"Cellulose\",\"volume\":\"32 14\",\"pages\":\"8547 - 8565\"},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2025-08-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cellulose\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s10570-025-06673-x\",\"RegionNum\":2,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, PAPER & WOOD\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cellulose","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s10570-025-06673-x","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, PAPER & WOOD","Score":null,"Total":0}
Synthesis of alpha-tocopherol-loaded bovine serum albumin nanostructures and their impregnation on cellulose fabric for potential biomedical application
This study employed the desolvation method to encapsulate alpha-tocopherol encapsulation in the bovine serum albumin (BSA) nanoparticles (NPs). Alpha-tocopherol is an effective antioxidant; however, it is poorly stable in oxidizing environments. It was expected that the stability of alpha-tocopherol could be improved when capped in suitable micellar structures. BSA is a bio-compatible, biodegradable, and non-toxic material and can be used to encapsulate alpha-tocopherol to increase its stability and acquire a controlled release. The BSA-encapsulated alpha-tocopherol-loaded NPs were applied to cellulose fabric. The BSA nanoparticles (BNPs) and alpha-tocopherol loaded-BNPs were characterized using UV–vis spectrophotometry, dynamic light scattering, differential scanning calorimetry, Fourier-transform infrared and stability analyses. The results demonstrated the spherical morphology of NPs, as observed under the SEM machine. The unloaded BNPs expressed the z-average size of 92 ± 5 nm, which became 95 ± 5–194 ± 5 depending on alpha-tocopherol loading. The FTIR analysis confirmed the successful impregnation of alpha-tocopherol in the BNPs. The alpha-tocopherol-loaded BNPs expressed up to 68 ± 4% release at the pH of 7.4. The alpha-tocopherol encapsulated in BNPs in the presence of rhamnolipid surfactant expressed in a controlled release in the buffer media. The tensile strength and elongation at the break values of untreated fabric were observed as 63 ± 3 MPa and 18 ± 1%, which increased to 92 ± 5 MPa and 25 ± 1%, respectively, on treatment with alpha-tocopherol-loaded BNPs at 200 mg/g. The alpha-tocopherol-loaded BNP-treated cellulose fabric exhibited more finish release (66 ± 3%) at 7.4 whereas limited (23 ± 2–25 ± 2%) in the pH range 5.4–6.4, i.e., the finish stability and release were pH-sensitive. Overall, the study focused on the development of sustainable drug delivery systems using renewable materials, like BSA as the shell matrix, alpha-tocopherol as an antioxidant, rhamnolipid as biosurfactant, cellulose as the substrate and citric acid as an eco-friendly cross-linker. The hence-produced cellulose fabric treated with alpha-tocopherol-loaded BSA inclusions expressed exceptional antioxidant activity and comfort properties. It thus can offer numerous benefits in the healthcare sector in skin care, eczema, and cosmetotextiles.
期刊介绍:
Cellulose is an international journal devoted to the dissemination of research and scientific and technological progress in the field of cellulose and related naturally occurring polymers. The journal is concerned with the pure and applied science of cellulose and related materials, and also with the development of relevant new technologies. This includes the chemistry, biochemistry, physics and materials science of cellulose and its sources, including wood and other biomass resources, and their derivatives. Coverage extends to the conversion of these polymers and resources into manufactured goods, such as pulp, paper, textiles, and manufactured as well natural fibers, and to the chemistry of materials used in their processing. Cellulose publishes review articles, research papers, and technical notes.