负载α -生育酚的牛血清白蛋白纳米结构的合成及其在纤维素织物上的浸渍

IF 4.8 2区 工程技术 Q1 MATERIALS SCIENCE, PAPER & WOOD
Sadia Latif, Zulfiqar Ali Raza, Mina Hafeez, Tazeen Riaz, Rashid Masood
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引用次数: 0

摘要

本研究采用脱溶法将α -生育酚包封在牛血清白蛋白纳米颗粒(NPs)中。-生育酚是一种有效的抗氧化剂;然而,它在氧化环境中稳定性差。结果表明,采用合适的胶束结构可以提高α -生育酚的稳定性。BSA是一种生物相容性、可生物降解、无毒的材料,可用于包封α -生育酚,以增加其稳定性并获得控释。将bsa包封的α -生育酚负载NPs应用于纤维素织物。采用紫外-可见分光光度法、动态光散射法、差示扫描量热法、傅里叶变换红外光谱法和稳定性分析对BSA纳米颗粒及其负载的α -生育酚进行了表征。结果表明,在扫描电镜下观察到NPs的球形形貌。未加载的BNPs表达的z-平均尺寸为92±5 nm,根据α -生育酚负载的不同,z-平均尺寸为95±5 - 194±5。FTIR分析证实了α -生育酚在bnp中的成功浸渍。在pH为7.4时,α -生育酚负载的BNPs的释放量高达68±4%。α -生育酚在鼠李糖脂表面活性剂的存在下被包裹在BNPs中,在缓冲介质中以可控释放的方式表达。未处理织物的抗拉强度和断裂伸长率分别为63±3 MPa和18±1%,添加200 mg/g α -生育酚的BNPs处理后,拉伸强度和断裂伸长率分别为92±5 MPa和25±1%。负载α -生育酚的bnp处理的纤维素织物在pH值为7.4时释放量较大(66±3%),而在pH值为5.4-6.4时释放量有限(23±2-25±2%),即整理稳定性和释放量对pH值敏感。总体而言,该研究的重点是使用可再生材料开发可持续的药物传递系统,如BSA作为外壳基质,α -生育酚作为抗氧化剂,鼠李糖脂作为生物表面活性剂,纤维素作为底物,柠檬酸作为环保交联剂。由此产生的纤维素织物经α -生育酚负载的BSA包体处理后,表现出优异的抗氧化活性和舒适性能。因此,它可以在皮肤护理、湿疹和化妆品纺织等医疗保健领域提供许多好处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthesis of alpha-tocopherol-loaded bovine serum albumin nanostructures and their impregnation on cellulose fabric for potential biomedical application

This study employed the desolvation method to encapsulate alpha-tocopherol encapsulation in the bovine serum albumin (BSA) nanoparticles (NPs). Alpha-tocopherol is an effective antioxidant; however, it is poorly stable in oxidizing environments. It was expected that the stability of alpha-tocopherol could be improved when capped in suitable micellar structures. BSA is a bio-compatible, biodegradable, and non-toxic material and can be used to encapsulate alpha-tocopherol to increase its stability and acquire a controlled release. The BSA-encapsulated alpha-tocopherol-loaded NPs were applied to cellulose fabric. The BSA nanoparticles (BNPs) and alpha-tocopherol loaded-BNPs were characterized using UV–vis spectrophotometry, dynamic light scattering, differential scanning calorimetry, Fourier-transform infrared and stability analyses. The results demonstrated the spherical morphology of NPs, as observed under the SEM machine. The unloaded BNPs expressed the z-average size of 92 ± 5 nm, which became 95 ± 5–194 ± 5 depending on alpha-tocopherol loading. The FTIR analysis confirmed the successful impregnation of alpha-tocopherol in the BNPs. The alpha-tocopherol-loaded BNPs expressed up to 68 ± 4% release at the pH of 7.4. The alpha-tocopherol encapsulated in BNPs in the presence of rhamnolipid surfactant expressed in a controlled release in the buffer media. The tensile strength and elongation at the break values of untreated fabric were observed as 63 ± 3 MPa and 18 ± 1%, which increased to 92 ± 5 MPa and 25 ± 1%, respectively, on treatment with alpha-tocopherol-loaded BNPs at 200 mg/g. The alpha-tocopherol-loaded BNP-treated cellulose fabric exhibited more finish release (66 ± 3%) at 7.4 whereas limited (23 ± 2–25 ± 2%) in the pH range 5.4–6.4, i.e., the finish stability and release were pH-sensitive. Overall, the study focused on the development of sustainable drug delivery systems using renewable materials, like BSA as the shell matrix, alpha-tocopherol as an antioxidant, rhamnolipid as biosurfactant, cellulose as the substrate and citric acid as an eco-friendly cross-linker. The hence-produced cellulose fabric treated with alpha-tocopherol-loaded BSA inclusions expressed exceptional antioxidant activity and comfort properties. It thus can offer numerous benefits in the healthcare sector in skin care, eczema, and cosmetotextiles.

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来源期刊
Cellulose
Cellulose 工程技术-材料科学:纺织
CiteScore
10.10
自引率
10.50%
发文量
580
审稿时长
3-8 weeks
期刊介绍: Cellulose is an international journal devoted to the dissemination of research and scientific and technological progress in the field of cellulose and related naturally occurring polymers. The journal is concerned with the pure and applied science of cellulose and related materials, and also with the development of relevant new technologies. This includes the chemistry, biochemistry, physics and materials science of cellulose and its sources, including wood and other biomass resources, and their derivatives. Coverage extends to the conversion of these polymers and resources into manufactured goods, such as pulp, paper, textiles, and manufactured as well natural fibers, and to the chemistry of materials used in their processing. Cellulose publishes review articles, research papers, and technical notes.
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