Ya-Xin Li, Dong-Mei Ma, Xing-Ming Zhao, Jun Xiang, Fu-Fa Wu and Rong-Da Zhao
{"title":"基于异质结结构COF/Co3O4/MWCNT的新型电化学生物传感器：能够检测复杂基质中的多巴胺和尿酸","authors":"Ya-Xin Li, Dong-Mei Ma, Xing-Ming Zhao, Jun Xiang, Fu-Fa Wu and Rong-Da Zhao","doi":"10.1039/D5NJ02394G","DOIUrl":null,"url":null,"abstract":"<p >Dopamine (DA) and uric acid (UA) play pivotal roles in the human central nervous system, necessitating the urgent development of a rapid, specific, and highly sensitive detection method for the early diagnosis and treatment of related diseases. This study presents the creation of an electrochemical biosensor made from a composite material known as COF/Co<small><sub>3</sub></small>O<small><sub>4</sub></small>/MWCNT, which allows for the simultaneous detection of DA and UA. The enhancements in adsorption and enrichment of the COF/Co<small><sub>3</sub></small>O<small><sub>4</sub></small>/MWCNT composite for both DA and UA were notably improved through the incorporation of MWCNTs. The developed electrochemical sensor has detection limits (LOD) of 0.013 μM and 0.046 μM for DA and UA, respectively, with a linear range of 0.1 μM to 500 μM for each analyte. Furthermore, the sensor demonstrates impressive features such as strong selectivity, consistent reproducibility, resistance to interference, and stability over extended periods.</p>","PeriodicalId":95,"journal":{"name":"New Journal of Chemistry","volume":" 37","pages":" 16307-16319"},"PeriodicalIF":2.5000,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A novel electrochemical biosensor based on a heterojunction-structured COF/Co3O4/MWCNT: enabling the detection of dopamine and uric acid in complex matrices\",\"authors\":\"Ya-Xin Li, Dong-Mei Ma, Xing-Ming Zhao, Jun Xiang, Fu-Fa Wu and Rong-Da Zhao\",\"doi\":\"10.1039/D5NJ02394G\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Dopamine (DA) and uric acid (UA) play pivotal roles in the human central nervous system, necessitating the urgent development of a rapid, specific, and highly sensitive detection method for the early diagnosis and treatment of related diseases. This study presents the creation of an electrochemical biosensor made from a composite material known as COF/Co<small><sub>3</sub></small>O<small><sub>4</sub></small>/MWCNT, which allows for the simultaneous detection of DA and UA. The enhancements in adsorption and enrichment of the COF/Co<small><sub>3</sub></small>O<small><sub>4</sub></small>/MWCNT composite for both DA and UA were notably improved through the incorporation of MWCNTs. The developed electrochemical sensor has detection limits (LOD) of 0.013 μM and 0.046 μM for DA and UA, respectively, with a linear range of 0.1 μM to 500 μM for each analyte. Furthermore, the sensor demonstrates impressive features such as strong selectivity, consistent reproducibility, resistance to interference, and stability over extended periods.</p>\",\"PeriodicalId\":95,\"journal\":{\"name\":\"New Journal of Chemistry\",\"volume\":\" 37\",\"pages\":\" 16307-16319\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-08-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"New Journal of Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2025/nj/d5nj02394g\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"New Journal of Chemistry","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/nj/d5nj02394g","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
A novel electrochemical biosensor based on a heterojunction-structured COF/Co3O4/MWCNT: enabling the detection of dopamine and uric acid in complex matrices
Dopamine (DA) and uric acid (UA) play pivotal roles in the human central nervous system, necessitating the urgent development of a rapid, specific, and highly sensitive detection method for the early diagnosis and treatment of related diseases. This study presents the creation of an electrochemical biosensor made from a composite material known as COF/Co3O4/MWCNT, which allows for the simultaneous detection of DA and UA. The enhancements in adsorption and enrichment of the COF/Co3O4/MWCNT composite for both DA and UA were notably improved through the incorporation of MWCNTs. The developed electrochemical sensor has detection limits (LOD) of 0.013 μM and 0.046 μM for DA and UA, respectively, with a linear range of 0.1 μM to 500 μM for each analyte. Furthermore, the sensor demonstrates impressive features such as strong selectivity, consistent reproducibility, resistance to interference, and stability over extended periods.
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