{"title":"探索信号驱动的基因多样性:一种新的级联方法","authors":"Zhenzhen Guo , Haowen Chen , Wenjie Cao , Huahai Qiu , Tianshou Zhou","doi":"10.1016/j.cjph.2025.09.007","DOIUrl":null,"url":null,"abstract":"<div><div>Cells must have the ability to respond to various external signals, but our understanding of this signal response is very limited. Here we analyze a simple cascade model of stochastic gene expression, which assumes that the upstream (input) gene is expressed in a constitutive manner whereas the downstream (output) gene is expressed in a bursty fashion via a two-state model, and that the former regulates the latter via transcription factors (products of the former). By large scale sampling in the space of model parameters, we find that the output distributions can exhibit diverse patterns such as unimodal, bimodal or trimodal modes, depending on the regulation way (positive or negative). These patterns, which are different from those in the case of no regulation, are independent of the choice of parameter values and hence qualitatively invariant. Diverse expression patterns resulting from signal response would be important for cell fate decisions and utilized by cells for a better survival in complex environments.</div></div>","PeriodicalId":10340,"journal":{"name":"Chinese Journal of Physics","volume":"98 ","pages":"Pages 125-136"},"PeriodicalIF":4.6000,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring signal-driven gene diversity: a novel cascade approach\",\"authors\":\"Zhenzhen Guo , Haowen Chen , Wenjie Cao , Huahai Qiu , Tianshou Zhou\",\"doi\":\"10.1016/j.cjph.2025.09.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Cells must have the ability to respond to various external signals, but our understanding of this signal response is very limited. Here we analyze a simple cascade model of stochastic gene expression, which assumes that the upstream (input) gene is expressed in a constitutive manner whereas the downstream (output) gene is expressed in a bursty fashion via a two-state model, and that the former regulates the latter via transcription factors (products of the former). By large scale sampling in the space of model parameters, we find that the output distributions can exhibit diverse patterns such as unimodal, bimodal or trimodal modes, depending on the regulation way (positive or negative). These patterns, which are different from those in the case of no regulation, are independent of the choice of parameter values and hence qualitatively invariant. Diverse expression patterns resulting from signal response would be important for cell fate decisions and utilized by cells for a better survival in complex environments.</div></div>\",\"PeriodicalId\":10340,\"journal\":{\"name\":\"Chinese Journal of Physics\",\"volume\":\"98 \",\"pages\":\"Pages 125-136\"},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2025-09-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chinese Journal of Physics\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0577907325003570\",\"RegionNum\":2,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PHYSICS, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Journal of Physics","FirstCategoryId":"101","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0577907325003570","RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSICS, MULTIDISCIPLINARY","Score":null,"Total":0}
Exploring signal-driven gene diversity: a novel cascade approach
Cells must have the ability to respond to various external signals, but our understanding of this signal response is very limited. Here we analyze a simple cascade model of stochastic gene expression, which assumes that the upstream (input) gene is expressed in a constitutive manner whereas the downstream (output) gene is expressed in a bursty fashion via a two-state model, and that the former regulates the latter via transcription factors (products of the former). By large scale sampling in the space of model parameters, we find that the output distributions can exhibit diverse patterns such as unimodal, bimodal or trimodal modes, depending on the regulation way (positive or negative). These patterns, which are different from those in the case of no regulation, are independent of the choice of parameter values and hence qualitatively invariant. Diverse expression patterns resulting from signal response would be important for cell fate decisions and utilized by cells for a better survival in complex environments.
期刊介绍:
The Chinese Journal of Physics publishes important advances in various branches in physics, including statistical and biophysical physics, condensed matter physics, atomic/molecular physics, optics, particle physics and nuclear physics.
The editors welcome manuscripts on:
-General Physics: Statistical and Quantum Mechanics, etc.-
Gravitation and Astrophysics-
Elementary Particles and Fields-
Nuclear Physics-
Atomic, Molecular, and Optical Physics-
Quantum Information and Quantum Computation-
Fluid Dynamics, Nonlinear Dynamics, Chaos, and Complex Networks-
Plasma and Beam Physics-
Condensed Matter: Structure, etc.-
Condensed Matter: Electronic Properties, etc.-
Polymer, Soft Matter, Biological, and Interdisciplinary Physics.
CJP publishes regular research papers, feature articles and review papers.