HOXA7可用于胶质瘤的预后评估和分子靶向治疗：一项基于大样本量的多维研究

IF 2.2 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry and Biophysics Reports Pub Date : 2025-09-22 DOI:10.1016/j.bbrep.2025.102279

Zhi Sha , Zhendong Liu , Yanzheng Gao

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引用次数: 0

摘要

据报道，HOXA7在多种恶性肿瘤中发挥重要作用；然而，其在胶质瘤中的作用尚未阐明。本回顾性研究旨在通过多维度分析，全面探讨HOXA7在胶质瘤中的表达规律、临床意义及可能的分子机制。本研究基于来自不同数据库的1946个胶质瘤的大样本，采用多种统计学和生物信息学方法，从多个水平（mRNA、细胞信号通路、临床特征和预后）探索HOXA7在胶质瘤中的作用。HOXA7在胶质瘤中异常高表达，其表达水平可作为胶质瘤的独立预后因素，同时具有一定的临床诊断价值。此外，HOXA7可能参与调控一些与癌症相关的细胞信号通路，如泛酸和辅酶a的生物合成。HOXA7异常高表达可能与多种临床特征及肿瘤相关细胞信号通路显著相关，可作为胶质瘤预后评价的生物标志物和分子靶点。

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HOXA7 can be used for prognostic evaluation and molecular targeted therapy of gliomas: a multidimensional study based on a large sample size

HOXA7 has been reported to play an important role in various malignant tumors; however, its role in gliomas has not yet been elucidated. This retrospective study aimed to comprehensively investigate the expression patterns, clinical significance, and potential molecular mechanisms of HOXA7 in gliomas through multi-dimensional analysis. Based on a large sample size of 1946 gliomas from various databases, this study used a variety of statistical and bioinformatics methods to explore the role of HOXA7 in gliomas at multiple levels (mRNA, cell signaling pathways, clinical characteristics, and prognosis). HOXA7 has abnormally high expression in gliomas, and its expression level can be used as an independent prognostic factor for gliomas, as well as having some clinical diagnostic value. In addition, HOXA7 may be involved in the regulation of some cancer-related cell signaling pathways, such as pantothenate and CoA biosynthesis. Abnormally high expression of HOXA7 may be significantly correlated with multiple clinical features and cancer-related cell signaling pathways, and it may be used as a biomarker and molecular target for evaluating prognosis of gliomas.

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来源期刊

Biochemistry and Biophysics Reports Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

191

审稿时长

59 days

期刊介绍： Open access, online only, peer-reviewed international journal in the Life Sciences, established in 2014 Biochemistry and Biophysics Reports (BB Reports) publishes original research in all aspects of Biochemistry, Biophysics and related areas like Molecular and Cell Biology. BB Reports welcomes solid though more preliminary, descriptive and small scale results if they have the potential to stimulate and/or contribute to future research, leading to new insights or hypothesis. Primary criteria for acceptance is that the work is original, scientifically and technically sound and provides valuable knowledge to life sciences research. We strongly believe all results deserve to be published and documented for the advancement of science. BB Reports specifically appreciates receiving reports on: Negative results, Replication studies, Reanalysis of previous datasets.