腺苷负载的粘合剂微流体水凝胶微球刺激穴位激活疼痛管理

IF 7.9 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Xiujuan Li , Zehao Chen , Songgen Chen , Han Wang , Lin Fu , Ban Feng , Hui Chen , Lize Xiong
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引用次数: 0

摘要

疼痛是一项重大的公共卫生挑战,具有巨大的临床和经济负担。虽然药物治疗仍然是疼痛管理的支柱,但其效用受到不良副作用和潜在依赖性的限制。针灸通过穴位刺激产生镇痛效果,在疼痛管理方面显示出巨大的潜力。然而,其特异性差和不明确的刺激参数损害了治疗特异性和可重复性。在此,我们开发了一种基于生物材料的穴位激活策略来治疗疼痛。采用微流控技术制备粘接聚多巴胺包被水凝胶微球,实现穴位的准确附着和激活。载腺苷的黏附水凝胶微球可在ST36穴位缓慢释放外源性腺苷,模拟针刺镇痛作用。体外和体内研究表明,单次给药黏附微球可以有效靶向穴位,提高机械痛阈,并提供长达7天的全身抗炎作用。总的来说,所提出的黏附水凝胶微球系统为针灸实践和疼痛管理提供了新的视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Adenosine-loaded adhesive microfluidic hydrogel microspheres stimulate acupoint activation for pain management

Adenosine-loaded adhesive microfluidic hydrogel microspheres stimulate acupoint activation for pain management
Pain represents a significant public health challenge with substantial clinical and economic burdens. While pharmacotherapy remains a mainstay of pain management, its utility is limited by adverse side effects and the potential for dependency. Acupuncture has shown great potential in pain management through its ability to induce analgesic effects via acupoint stimulation. However, its poor specificity and ill-defined stimulation parameters compromise therapeutic specificity and reproducibility. Herein, we developed a biomaterial-based acupoint activation strategy for pain management. Adhesive polydopamine-coated hydrogel microspheres were fabricated using microfluidic techniques for accurate attachment and activation of acupoints. Adhesive hydrogel microspheres loaded with adenosine can slowly release exogenous adenosine at the ST36 acupoint to simulate the analgesic effect of acupuncture. In vitro and in vivo studies demonstrated that single-dose administration of adhesive microspheres can effectively target acupoints, elevate mechanical pain thresholds, and provide systemic anti-inflammatory effects for up to 7 days. Overall, the proposed adhesive hydrogel microsphere system offers a new perspective on acupuncture practice and pain management.
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来源期刊
Materials & Design
Materials & Design Engineering-Mechanical Engineering
CiteScore
14.30
自引率
7.10%
发文量
1028
审稿时长
85 days
期刊介绍: Materials and Design is a multi-disciplinary journal that publishes original research reports, review articles, and express communications. The journal focuses on studying the structure and properties of inorganic and organic materials, advancements in synthesis, processing, characterization, and testing, the design of materials and engineering systems, and their applications in technology. It aims to bring together various aspects of materials science, engineering, physics, and chemistry. The journal explores themes ranging from materials to design and aims to reveal the connections between natural and artificial materials, as well as experiment and modeling. Manuscripts submitted to Materials and Design should contain elements of discovery and surprise, as they often contribute new insights into the architecture and function of matter.
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