Dongjie Fu , Yuerong Wang , Jiaqi Xuan , Dingchang Liu , Jiawei Zhao , Yang Lei , Tianwen Xi , Hui Yang , Leming Sun
{"title":"硼替佐米纳米纤维自组装用于实体瘤和骨转移治疗","authors":"Dongjie Fu , Yuerong Wang , Jiaqi Xuan , Dingchang Liu , Jiawei Zhao , Yang Lei , Tianwen Xi , Hui Yang , Leming Sun","doi":"10.1016/j.matdes.2025.114758","DOIUrl":null,"url":null,"abstract":"<div><div>To overcome challenges including insufficient drug loading capacity, limited targeting accuracy, and the complex preparation of conventional nanomedicine, self-assembled nanomaterials have emerged as a viable solution. To explore the peptide self-assembly theory and overcome limitations, this study used bortezomib (BTZ) as the base material, and a novel peptide self-assembly strategy utilizing Zn(II) coordination was employed to prepare cancer cell-targeting nanofiber drugs (cRGD-BTZNDs). The therapeutic efficacy was evaluated in different types of tumors. The results demonstrated that cRGD-BTZNDs effectively entered cancer cells and exhibited enhanced cytotoxic effects against cancer cells compared to BTZ. Moreover, cRGD-BTZNDs exhibited excellent therapeutic efficacy against solid tumors, significantly inhibiting 4 T1 tumor growth while reducing biological toxicity. Additionally, in the treatment of bone metastases, cRGD-BTZNDs demonstrated excellent therapeutic potency, effectively alleviating bone damage in mice with high biocompatibility. This study not only self-assembled nanomaterials with great potential in cancer therapy, but also affirmed the correctness and universality of the Zn(II) coordination peptide self-assembly theory, providing a theoretical basis for the improvement of peptide-based nanomedicine.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"259 ","pages":"Article 114758"},"PeriodicalIF":7.9000,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Self-assembly of bortezomib nanofibers for solid tumor and bone metastasis therapy\",\"authors\":\"Dongjie Fu , Yuerong Wang , Jiaqi Xuan , Dingchang Liu , Jiawei Zhao , Yang Lei , Tianwen Xi , Hui Yang , Leming Sun\",\"doi\":\"10.1016/j.matdes.2025.114758\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>To overcome challenges including insufficient drug loading capacity, limited targeting accuracy, and the complex preparation of conventional nanomedicine, self-assembled nanomaterials have emerged as a viable solution. To explore the peptide self-assembly theory and overcome limitations, this study used bortezomib (BTZ) as the base material, and a novel peptide self-assembly strategy utilizing Zn(II) coordination was employed to prepare cancer cell-targeting nanofiber drugs (cRGD-BTZNDs). The therapeutic efficacy was evaluated in different types of tumors. The results demonstrated that cRGD-BTZNDs effectively entered cancer cells and exhibited enhanced cytotoxic effects against cancer cells compared to BTZ. Moreover, cRGD-BTZNDs exhibited excellent therapeutic efficacy against solid tumors, significantly inhibiting 4 T1 tumor growth while reducing biological toxicity. Additionally, in the treatment of bone metastases, cRGD-BTZNDs demonstrated excellent therapeutic potency, effectively alleviating bone damage in mice with high biocompatibility. This study not only self-assembled nanomaterials with great potential in cancer therapy, but also affirmed the correctness and universality of the Zn(II) coordination peptide self-assembly theory, providing a theoretical basis for the improvement of peptide-based nanomedicine.</div></div>\",\"PeriodicalId\":383,\"journal\":{\"name\":\"Materials & Design\",\"volume\":\"259 \",\"pages\":\"Article 114758\"},\"PeriodicalIF\":7.9000,\"publicationDate\":\"2025-09-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Materials & Design\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0264127525011785\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials & Design","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0264127525011785","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Self-assembly of bortezomib nanofibers for solid tumor and bone metastasis therapy
To overcome challenges including insufficient drug loading capacity, limited targeting accuracy, and the complex preparation of conventional nanomedicine, self-assembled nanomaterials have emerged as a viable solution. To explore the peptide self-assembly theory and overcome limitations, this study used bortezomib (BTZ) as the base material, and a novel peptide self-assembly strategy utilizing Zn(II) coordination was employed to prepare cancer cell-targeting nanofiber drugs (cRGD-BTZNDs). The therapeutic efficacy was evaluated in different types of tumors. The results demonstrated that cRGD-BTZNDs effectively entered cancer cells and exhibited enhanced cytotoxic effects against cancer cells compared to BTZ. Moreover, cRGD-BTZNDs exhibited excellent therapeutic efficacy against solid tumors, significantly inhibiting 4 T1 tumor growth while reducing biological toxicity. Additionally, in the treatment of bone metastases, cRGD-BTZNDs demonstrated excellent therapeutic potency, effectively alleviating bone damage in mice with high biocompatibility. This study not only self-assembled nanomaterials with great potential in cancer therapy, but also affirmed the correctness and universality of the Zn(II) coordination peptide self-assembly theory, providing a theoretical basis for the improvement of peptide-based nanomedicine.
期刊介绍:
Materials and Design is a multi-disciplinary journal that publishes original research reports, review articles, and express communications. The journal focuses on studying the structure and properties of inorganic and organic materials, advancements in synthesis, processing, characterization, and testing, the design of materials and engineering systems, and their applications in technology. It aims to bring together various aspects of materials science, engineering, physics, and chemistry.
The journal explores themes ranging from materials to design and aims to reveal the connections between natural and artificial materials, as well as experiment and modeling. Manuscripts submitted to Materials and Design should contain elements of discovery and surprise, as they often contribute new insights into the architecture and function of matter.