基于薯蓣皂苷元的纳米医学：配方策略、生物医学应用和转化挑战的进展

IF 5.45 Q1 Physics and Astronomy

Nano-Structures & Nano-Objects Pub Date : 2025-09-20 DOI:10.1016/j.nanoso.2025.101556

Seyed Mohammad Amini

{"title":"基于薯蓣皂苷元的纳米医学：配方策略、生物医学应用和转化挑战的进展","authors":"Seyed Mohammad Amini","doi":"10.1016/j.nanoso.2025.101556","DOIUrl":null,"url":null,"abstract":"<div><div>Diosgenin, a natural phytochemical, is promising in treating various diseases, including cancer, diabetes, arthritis, asthma, and cardiovascular conditions. Notably, it serves as a crucial raw material in the production of several steroid medications within the pharmaceutical industry. Given the vast array of opportunities presented by nanotechnology in the field of biomedicine, substantial research efforts have focused on the development of diverse nanoformulations derived from natural compounds, including diosgenin. This review examines a range of studies regarding the application of diosgenin in preparing nanomaterials, as well as the utilization of nanomaterials for the production, application, or delivery of diosgenin itself. Key insights into the remarkable potential of diosgenin within medical nanotechnology are emphasized. Its hydrophobic nature allows for efficient loading by organic nanostructures, enhancing its bioavailability in the body. Beyond its therapeutic attributes, due to its high chemical activity, diosgenin can act as a precursor for synthesizing various precursors for preparing organic or inorganic nanoparticles.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"44 ","pages":"Article 101556"},"PeriodicalIF":5.4500,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Diosgenin-based nanomedicine: Advances in formulation strategies, biomedical applications, and translational challenges\",\"authors\":\"Seyed Mohammad Amini\",\"doi\":\"10.1016/j.nanoso.2025.101556\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Diosgenin, a natural phytochemical, is promising in treating various diseases, including cancer, diabetes, arthritis, asthma, and cardiovascular conditions. Notably, it serves as a crucial raw material in the production of several steroid medications within the pharmaceutical industry. Given the vast array of opportunities presented by nanotechnology in the field of biomedicine, substantial research efforts have focused on the development of diverse nanoformulations derived from natural compounds, including diosgenin. This review examines a range of studies regarding the application of diosgenin in preparing nanomaterials, as well as the utilization of nanomaterials for the production, application, or delivery of diosgenin itself. Key insights into the remarkable potential of diosgenin within medical nanotechnology are emphasized. Its hydrophobic nature allows for efficient loading by organic nanostructures, enhancing its bioavailability in the body. Beyond its therapeutic attributes, due to its high chemical activity, diosgenin can act as a precursor for synthesizing various precursors for preparing organic or inorganic nanoparticles.</div></div>\",\"PeriodicalId\":397,\"journal\":{\"name\":\"Nano-Structures & Nano-Objects\",\"volume\":\"44 \",\"pages\":\"Article 101556\"},\"PeriodicalIF\":5.4500,\"publicationDate\":\"2025-09-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nano-Structures & Nano-Objects\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2352507X2500126X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Physics and Astronomy\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano-Structures & Nano-Objects","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2352507X2500126X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Physics and Astronomy","Score":null,"Total":0}

引用次数: 0

摘要

薯蓣皂苷元是一种天然的植物化学物质，在治疗各种疾病方面很有前景，包括癌症、糖尿病、关节炎、哮喘和心血管疾病。值得注意的是，它是制药工业中几种类固醇药物生产的关键原料。鉴于纳米技术在生物医学领域提供的大量机会，大量的研究工作集中在开发从天然化合物衍生的各种纳米配方上，包括薯蓣皂苷元。本文综述了薯蓣皂苷元在制备纳米材料中的应用，以及纳米材料在薯蓣皂苷元本身的生产、应用或递送中的应用。重点洞察薯蓣皂苷元的显著潜力在医疗纳米技术强调。它的疏水性允许有机纳米结构有效负载，提高其在体内的生物利用度。除了其治疗特性，由于其高化学活性，薯蓣皂苷元可以作为合成各种前体的前体，用于制备有机或无机纳米颗粒。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Diosgenin-based nanomedicine: Advances in formulation strategies, biomedical applications, and translational challenges

Diosgenin, a natural phytochemical, is promising in treating various diseases, including cancer, diabetes, arthritis, asthma, and cardiovascular conditions. Notably, it serves as a crucial raw material in the production of several steroid medications within the pharmaceutical industry. Given the vast array of opportunities presented by nanotechnology in the field of biomedicine, substantial research efforts have focused on the development of diverse nanoformulations derived from natural compounds, including diosgenin. This review examines a range of studies regarding the application of diosgenin in preparing nanomaterials, as well as the utilization of nanomaterials for the production, application, or delivery of diosgenin itself. Key insights into the remarkable potential of diosgenin within medical nanotechnology are emphasized. Its hydrophobic nature allows for efficient loading by organic nanostructures, enhancing its bioavailability in the body. Beyond its therapeutic attributes, due to its high chemical activity, diosgenin can act as a precursor for synthesizing various precursors for preparing organic or inorganic nanoparticles.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Nano-Structures & Nano-Objects Physics and Astronomy-Condensed Matter Physics

CiteScore

9.20

自引率

0.00%

发文量

审稿时长

22 days

期刊介绍： Nano-Structures & Nano-Objects is a new journal devoted to all aspects of the synthesis and the properties of this new flourishing domain. The journal is devoted to novel architectures at the nano-level with an emphasis on new synthesis and characterization methods. The journal is focused on the objects rather than on their applications. However, the research for new applications of original nano-structures & nano-objects in various fields such as nano-electronics, energy conversion, catalysis, drug delivery and nano-medicine is also welcome. The scope of Nano-Structures & Nano-Objects involves: -Metal and alloy nanoparticles with complex nanostructures such as shape control, core-shell and dumbells -Oxide nanoparticles and nanostructures, with complex oxide/metal, oxide/surface and oxide /organic interfaces -Inorganic semi-conducting nanoparticles (quantum dots) with an emphasis on new phases, structures, shapes and complexity -Nanostructures involving molecular inorganic species such as nanoparticles of coordination compounds, molecular magnets, spin transition nanoparticles etc. or organic nano-objects, in particular for molecular electronics -Nanostructured materials such as nano-MOFs and nano-zeolites -Hetero-junctions between molecules and nano-objects, between different nano-objects & nanostructures or between nano-objects & nanostructures and surfaces -Methods of characterization specific of the nano size or adapted for the nano size such as X-ray and neutron scattering, light scattering, NMR, Raman, Plasmonics, near field microscopies, various TEM and SEM techniques, magnetic studies, etc .