系统性红斑狼疮和Sjögren综合征中HBsAg阳性降低：一项回顾性比较研究

IF 2.2 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry and Biophysics Reports Pub Date : 2025-09-20 DOI:10.1016/j.bbrep.2025.102275

Man Li , Qihang Zhu , Zhong Fang , Taihong Huang , Lei Dai , Sen Wang

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引用次数: 0

摘要

系统性红斑狼疮（SLE）和Sjögren综合征（SS）是两种常见的系统性自身免疫性疾病。最近的研究表明，与一般人群相比，SLE患者的乙型肝炎表面抗原（HBsAg）患病率可能较低；然而，现有的证据仍然有限且存在争议。系统性分析SLE和SS患者的HBV感染率和血清学标志物分布可能为自身免疫和抗病毒免疫之间的相互作用提供重要见解。方法回顾性分析2019年1月至2024年12月南京鼓楼医院住院SLE患者2421例，SS患者2049例。其他自身免疫性疾病（包括类风湿关节炎（RA）、强直性脊柱炎（AS）、溃疡性结肠炎（UC）和克罗恩病（CD））患者和5927名非自身免疫性住院患者作为对照。检测乙型肝炎病毒（HBV）血清学标志物（HBsAg、HBsAb、HBeAg、HBeAb和HBcAb）和抗hcv抗体。我们比较了不同组中HBV血清标志物的阳性率，并根据性别、年龄和自身抗体谱进行了亚组分析。结果SLE和SS患者的HBsAg阳性率明显低于非自身免疫性对照组（分别为1.2% vs. 5.2%, P < 0.0001; 1.7% vs. 5.2%, P < 0.0001）。在RA、AS、UC或CD患者中没有观察到显著差异。分层分析显示，无论性别还是20岁以上的所有年龄组，SLE和SS患者的HBsAg阳性率均较低。进一步的分析表明，这一现象与隐蔽性HBV感染、住院与门诊状态或免疫抑制剂的使用无关。值得注意的是，高ANA滴度和抗dsdna、抗ssa和抗核糖体P等抗体的存在与较低的HBsAg阳性相关。有或无常见并发症患者的HBsAg阳性率无显著差异。结论sle和SS患者HBsAg阳性率均较低，与临床因素无关，且与自身抗体状态有关。这些发现提示疾病特异性免疫机制可能促进HBV清除或降低对感染的易感性。

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Reduced HBsAg positivity in systemic lupus erythematosus and Sjögren's syndrome: A retrospective comparative study

Background

Systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) are two common systemic autoimmune diseases. Recent studies have suggested that the prevalence of hepatitis B surface antigen (HBsAg) may be lower in patients with SLE compared to the general population; however, the existing evidence remains limited and controversial. A systematic analysis of HBV infection rates and serological marker distributions in patients with SLE and SS may offer important insights into the interaction between autoimmune and antiviral immunity.

Methods

We retrospectively analyzed 2421 hospitalized patients with SLE and 2049 with SS at Nanjing Drum Tower Hospital from January 2019 to December 2024. Patients with other autoimmune diseases (including rheumatoid arthritis (RA), ankylosing spondylitis (AS), ulcerative colitis (UC), and Crohn's disease (CD)) and 5927 non-autoimmune hospitalized patients were included as controls. Hepatitis B virus (HBV) serological markers (HBsAg, HBsAb, HBeAg, HBeAb, and HBcAb) and anti-HCV antibodies were tested. We compared the positivity rates of HBV seromarkers across different groups and performed subgroup analyses based on sex, age, and autoantibody profiles.

Results

The HBsAg positivity rate was significantly lower in SLE and SS patients compared with non-autoimmune controls (1.2 % vs. 5.2 %, P < 0.0001; 1.7 % vs. 5.2 %, P < 0.0001, respectively). No significant differences were observed in patients with RA, AS, UC, or CD. Stratified analyses revealed consistently lower HBsAg positivity in SLE and SS patients across both sexes and all age groups above 20 years. Further analyses indicated that this phenomenon was not attributable to occult HBV infection, inpatient versus outpatient status, or immunosuppressant use. Notably, high ANA titers and the presence of antibodies such as anti-dsDNA, anti-SSA, and anti-ribosomal P were associated with lower HBsAg positivity. No significant differences in HBsAg positivity were found between patients with or without common complications.

Conclusion

SLE and SS patients exhibit consistently lower HBsAg positivity rates, independent of clinical factors, and linked to autoantibody status. These findings suggest disease-specific immune mechanisms that may promote HBV clearance or reduce susceptibility to infection.

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来源期刊

Biochemistry and Biophysics Reports Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

191

审稿时长

59 days

期刊介绍： Open access, online only, peer-reviewed international journal in the Life Sciences, established in 2014 Biochemistry and Biophysics Reports (BB Reports) publishes original research in all aspects of Biochemistry, Biophysics and related areas like Molecular and Cell Biology. BB Reports welcomes solid though more preliminary, descriptive and small scale results if they have the potential to stimulate and/or contribute to future research, leading to new insights or hypothesis. Primary criteria for acceptance is that the work is original, scientifically and technically sound and provides valuable knowledge to life sciences research. We strongly believe all results deserve to be published and documented for the advancement of science. BB Reports specifically appreciates receiving reports on: Negative results, Replication studies, Reanalysis of previous datasets.