Brønsted酸催化丙烯氢硫基化和级联环化合成硫代铬化合物

IF 2.2 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-09-12 DOI:10.1016/j.tet.2025.134930

Chen-Yuan He , Ya-Qin Huang , Hao-Hua Feng , Xiao-Lin Qin , Si-Yuan Ma , Yang-Yang Zeng , Jie-Fang Meng , Li-Ping Pang , Yan-Min Huang

{"title":"Brønsted酸催化丙烯氢硫基化和级联环化合成硫代铬化合物","authors":"Chen-Yuan He , Ya-Qin Huang , Hao-Hua Feng , Xiao-Lin Qin , Si-Yuan Ma , Yang-Yang Zeng , Jie-Fang Meng , Li-Ping Pang , Yan-Min Huang","doi":"10.1016/j.tet.2025.134930","DOIUrl":null,"url":null,"abstract":"<div><div>Thiochromane is an important class of compound, which widely exists in many functional materials, pharmaceuticals, and natural products with biological activities, exhibiting anticancer, anti-inflammatory, antimalarial, and antibacterial properties. This study introduces a metal-free, green, and environmentally friendly synthetic strategy for the synthesis of thiochromane compounds through Brønsted acid-catalyzed hydrothiolation and cascade Friedel-Crafts cycloaddition of allenes, offering significant implications for the development and research of thiochromane compounds.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"187 ","pages":"Article 134930"},"PeriodicalIF":2.2000,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Brønsted acid-catalyzed hydrothiolation and cascade cyclization of allenes for the synthesis of thiochromane compounds\",\"authors\":\"Chen-Yuan He , Ya-Qin Huang , Hao-Hua Feng , Xiao-Lin Qin , Si-Yuan Ma , Yang-Yang Zeng , Jie-Fang Meng , Li-Ping Pang , Yan-Min Huang\",\"doi\":\"10.1016/j.tet.2025.134930\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Thiochromane is an important class of compound, which widely exists in many functional materials, pharmaceuticals, and natural products with biological activities, exhibiting anticancer, anti-inflammatory, antimalarial, and antibacterial properties. This study introduces a metal-free, green, and environmentally friendly synthetic strategy for the synthesis of thiochromane compounds through Brønsted acid-catalyzed hydrothiolation and cascade Friedel-Crafts cycloaddition of allenes, offering significant implications for the development and research of thiochromane compounds.</div></div>\",\"PeriodicalId\":437,\"journal\":{\"name\":\"Tetrahedron\",\"volume\":\"187 \",\"pages\":\"Article 134930\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-09-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tetrahedron\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0040402025004867\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040402025004867","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}

引用次数: 0

摘要

硫代铬烷是一类重要的化合物，广泛存在于许多功能材料、药物和具有生物活性的天然产物中，具有抗癌、抗炎、抗疟、抗菌等特性。本研究介绍了一种无金属、绿色、环保的合成策略，通过Brønsted酸催化氢硫基化和烯基级联Friedel-Crafts环加成合成硫代铬化合物，对硫代铬化合物的开发和研究具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Brønsted acid-catalyzed hydrothiolation and cascade cyclization of allenes for the synthesis of thiochromane compounds

查看原文本刊更多论文

Brønsted acid-catalyzed hydrothiolation and cascade cyclization of allenes for the synthesis of thiochromane compounds

Thiochromane is an important class of compound, which widely exists in many functional materials, pharmaceuticals, and natural products with biological activities, exhibiting anticancer, anti-inflammatory, antimalarial, and antibacterial properties. This study introduces a metal-free, green, and environmentally friendly synthetic strategy for the synthesis of thiochromane compounds through Brønsted acid-catalyzed hydrothiolation and cascade Friedel-Crafts cycloaddition of allenes, offering significant implications for the development and research of thiochromane compounds.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.