Ru（II）催化4-芳基喹唑啉-2(1H)- 1与炔酮的区域选择性[3+2]旋环反应

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-09-18 DOI:10.1016/j.tetlet.2025.155824

T. Ravi Teja , Ch. Ajay , S. Karthik , B. Sridhar , B.V. Subba Reddy

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引用次数: 0

摘要

利用Ru（II）络合物的催化量，通过[3+2]的螺旋环化反应，开发了一种新的4-芳基喹唑啉酮和炔酮之间的螺旋环化反应，生产出高刚性的螺旋喹唑啉酮支架。这种创新的策略产生了广泛的刚性螺旋化合物，具有优异的产量和显著的区域选择性。重要的是，这一过程涉及芳基（sp2）氢键的CH官能化，随后是亚胺官能化的烯基钌的亲核加成

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Ru(II)-catalyzed regioselective [3+2] spiroannulation of 4-arylquinazolin-2(1H)-ones with ynones

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Ru(II)-catalyzed regioselective [3+2] spiroannulation of 4-arylquinazolin-2(1H)-ones with ynones

A novel spiroannulation reaction between 4-arylquinazolinones and ynones has been developed to produce highly rigid spiroquinazolinone scaffolds through a [3+2] spirocyclization utilizing a catalytic amount of Ru(II) complex. This innovative strategy generates a broad spectrum of rigid spiro compounds in excellent yields with significant regioselectivity. Importantly, this process involves the CH functionalization of aryl (sp2)H bond followed by a nucleophilic addition of alkenyl ruthenium to imine functionality

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.