Volatilomics in diseases odour and electronic nose diagnosis

The innate human aspiration for health preservation and effective disease prevention represents a fundamental driver of civilizational progress. The large-scale screening and early diagnosis are valuable that the medical cost can be greatly reduced while prognostic trajectories are optimized. In this review article, the concepts, advances, and critical thinking on volatile markers of specific diseases (Volatilomics), electronic nose technology, and its applications in diagnosis through volatiles, are systematically introduced. This article provides valuable guidance for researchers in this interdisciplinary field, offering insights into state-of-the-art detection technologies for medical professionals while also assisting chemists, materials scientists, and electronics engineers in selecting target VOCs for sensor development.