增强器、消声器和衰减器：一种动态可逆的调节代码

IF 8.7 1区生物学 Q1 CELL BIOLOGY

Developmental cell Pub Date : 2025-09-22 DOI:10.1016/j.devcel.2025.06.039

Emily R. Wilson, Xiaoyang Zhang

引用次数: 0

摘要

通过顺式调控元件对基因表达进行精确的时空控制，是哺乳动物发育过程中多种细胞类型规范的必要条件。在本期的《发育细胞》中，Amblard等人剖析了尾鳍体发育过程中Cdx2表达的顺式调控逻辑，发现了一个动态调控代码微调基因表达。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Enhancers, silencers, and attenuators: A dynamic and reversible regulatory code

Precise spatial and temporal control of gene expression, orchestrated by cis-regulatory elements, is essential for diverse cell-type specification during mammalian development. In this issue of Developmental Cell, Amblard et al. dissect the cis-regulatory logic governing Cdx2 expression during caudal body development, identifying a dynamic regulatory code fine-tuning gene expression.

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来源期刊

Developmental cell 生物-发育生物学

CiteScore

18.90

自引率

1.70%

发文量

203

审稿时长

3-6 weeks

期刊介绍： Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.