结核病疫苗发展概况。

Q3 Medicine

Indian Journal of Tuberculosis Pub Date : 2025-01-19 DOI:10.1016/j.ijtb.2025.01.004

Banurekha Velayutham

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引用次数: 0

摘要

引进一种新型结核病疫苗将有助于减少结核病发病率，对实现消除结核病至关重要。鉴于卡介苗的局限性，需要开发能够在所有年龄组预防结核病发展的新型结核病疫苗。目前，从第一阶段到第三阶段，大约有17种疫苗处于临床开发阶段。它们属于不同的疫苗类型，即病毒载体疫苗、分枝杆菌灭活疫苗、分枝杆菌减毒活疫苗、蛋白质亚基疫苗和mRNA疫苗。正在开发的结核病疫苗旨在预防感染或疾病，防止复发或作为治疗性疫苗。目前还在评估重新接种卡介苗在预防结核病方面的作用。开发一种有效的结核病疫苗具有挑战性。基础科学研究、推进临床开发和确保公共卫生影响的研究在结核病疫苗开发中至关重要。让利益攸关方参与、确保资金和倡导支持可以加快开发新的结核病疫苗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Overview of the tuberculosis vaccine development landscape

The introduction of a novel tuberculosis (TB) vaccine will help to decrease TB incidence and is essential for achieving TB elimination. Given the limitations of BCG, there is a requirement for new vaccines for TB that can prevent the development of TB disease across all age groups. Currently, there are about 17 vaccines in clinical development from phase I to phase III. They belong to different vaccine types namely – viral vector, mycobacterial inactivated, mycobacterial live attenuated, protein subunit and mRNA vaccines. The TB vaccines in development are intended to prevent infection or disease, prevent recurrence or to act as therapeutic vaccines. Revaccination with BCG vaccine is also currently being evaluated in the prevention of TB. Developing an effective TB vaccine is challenging. Basic science research, advancing clinical development and research to ensure public health impact is crucial in TB vaccine development. Engaging stakeholders, securing funding, and advocating for support could expedite the development of new TB vaccines.

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来源期刊

Indian Journal of Tuberculosis Medicine-Infectious Diseases

CiteScore

2.80

自引率

0.00%

发文量

103

期刊介绍： Indian Journal of Tuberculosis (IJTB) is an international peer-reviewed journal devoted to the specialty of tuberculosis and lung diseases and is published quarterly. IJTB publishes research on clinical, epidemiological, public health and social aspects of tuberculosis. The journal accepts original research articles, viewpoints, review articles, success stories, interesting case series and case reports on patients suffering from pulmonary, extra-pulmonary tuberculosis as well as other respiratory diseases, Radiology Forum, Short Communications, Book Reviews, abstracts, letters to the editor, editorials on topics of current interest etc. The articles published in IJTB are a key source of information on research in tuberculosis. The journal is indexed in Medline