肺结核患者家庭接触者开始结核病预防治疗（TPT）的延迟：是否会影响TPT的结果？

Q3 Medicine

Indian Journal of Tuberculosis Pub Date : 2025-02-25 DOI:10.1016/j.ijtb.2025.02.016

Abhijit Dey , Ranjani Ramachandran , Dhrubajyoti Deka , Anamitra Barik , Bandita Sengupta , Iman Bhakta , Swarna Abhiman Ramteke , Sandip Roy , Asma Banu Varada , Arista Lahiri

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引用次数: 0

摘要

背景：结核病预防治疗（TPT）被认为是通过减少社区结核病感染池来降低结核病发病率的有效干预措施。本研究旨在评估西孟加拉邦TPT的结果及其相关性。方法：病理学：利用印度基于网络的结核病信息管理门户网站Ni-kshay的数据进行回顾性队列研究。所有在2022年开始使用TPT的TPT受益人都包括在研究中。为了找出与不成功结局相关的独立危险因素，采用回归模型计算风险比（RR）和调整风险比（aRR）。结果：参与者的中位年龄和BMI分别为32岁和20.9 kg/m2。从诊断为指数型结核病患者到开始TPT治疗的中位延迟时间为23天。90.5%（90.2 ~ 90.7）的结果为成功，9.5%（9.3 ~ 9.8）的结果为不良。0-9岁（aRR = 1.31）、10-19岁（aRR = 1.16）和20-39岁（aRR = 1.10）年龄组更容易出现TPT失败的结果。超重（aRR = 1.10）和肥胖（aRR = 1.19）与预后不佳相关。来自城市地区（aRR = 1.37）和私立医疗机构（aRR = 1.17）的参与者更有可能出现不成功的结果。TPT开始延迟8-30天（aRR = 2.03）和bb0 30天（aRR = 2.90）与TPT失败相关。结论：在西孟加拉邦的TPT项目中，差距很小，机会也很少。差距既存在于政策层面，也存在于执行层面。为了在西孟加拉邦制定更好的结核病预防战略，应该解决已确定的差距。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Delay in TB preventive treatment (TPT) initiation among household contacts of pulmonary TB patients: Does it affect the TPT outcome?

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Delay in TB preventive treatment (TPT) initiation among household contacts of pulmonary TB patients: Does it affect the TPT outcome?

Background

TB Preventive Treatment (TPT) is considered as an effective intervention to reduce TB incidence by reducing the pool of TB infection in the community. This study was aimed to assess TPT outcome and its associations in West Bengal.

Method

ology: A retrospective cohort study conducted using the data from Ni-kshay, the web-based TB information management portal of India. All TPT beneficiaries who have initiated with TPT in the year 2022 were included in the study. To find out the independent risk factor associated with unsuccessful outcome, risk ratio (RR) and adjusted risk ratio (aRR) has been calculated using regression models.

Results

Median age and BMI of the participants were 32 years, & 20.9 kg/m2 respectively. Median delay to TPT initiation from diagnosis of the index TB patients was 23 days. 90.5% (90.2–90.7) outcomes were successful while 9.5% (9.3–9.8) outcomes were unfavourable.

0–9yrs (aRR = 1.31), 10–19yrs (aRR = 1.16) & 20–39yrs (aRR = 1.10) age-groups were more likely to be associated with unsuccessful TPT outcomes. Overweight (aRR = 1.10) & Obese (aRR = 1.19) were associated with unsuccessful outcomes. Participants belong to urban areas (aRR = 1.37) & attending Private Health Facility (aRR = 1.17) were more likely to be associated with an unsuccessful outcome. TPT initiation delay of 8–30 days (aRR = 2.03) and >30 days (aRR = 2.90) was associated with unsuccessful TPT outcomes.

Conclusion

There are few gaps as well as few opportunities in the TPT programs in West Bengal. Gaps are both in policy level as well as implementation level. Identified gaps should be addressed for a better TB preventive strategy in West Bengal.

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来源期刊

Indian Journal of Tuberculosis Medicine-Infectious Diseases

CiteScore

2.80

自引率

0.00%

发文量

103

期刊介绍： Indian Journal of Tuberculosis (IJTB) is an international peer-reviewed journal devoted to the specialty of tuberculosis and lung diseases and is published quarterly. IJTB publishes research on clinical, epidemiological, public health and social aspects of tuberculosis. The journal accepts original research articles, viewpoints, review articles, success stories, interesting case series and case reports on patients suffering from pulmonary, extra-pulmonary tuberculosis as well as other respiratory diseases, Radiology Forum, Short Communications, Book Reviews, abstracts, letters to the editor, editorials on topics of current interest etc. The articles published in IJTB are a key source of information on research in tuberculosis. The journal is indexed in Medline