Are amyloid-based materials conducive to tissue engineering?

Amyloid fibrils, known for their stable, cross-β-sheet structure, are involved in both pathological conditions and functional biological processes. While implicated in disease pathogenesis, such as Alzheimer's and Parkinson's, they also play roles in normal cellular functions, such as biofilm formation, melanin polymerization, and hormone storage. Amyloid-based biomaterials have gained attention for their stability, mechanical strength, unique surface properties, and structural versatility, making them suitable for various biotechnological applications. This review discusses their recent advancements and potential as biomaterials for tissue engineering, such as scaffolds for cell culture, wound healing, and organoid development. The unique properties of amyloids, combined with advances in structural and synthetic biology, position them as promising candidates for innovative biomaterials in medical and biotechnological fields.