多功能聚（n -异丙基丙烯酰胺）基水凝胶具有止血、抗菌和药物缓释特性，用于感染伤口治疗。

IF 5.6 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-09-18 DOI:10.1016/j.colsurfb.2025.115147

Tao Gong , Ruolan Feng , Huirui Zhu , Moxuan Zhao , Baofeng Yu , Na Wang , Hongqin Wang , Rui Guo

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引用次数: 0

摘要

伤口感染阻碍愈合，加剧不适，并有严重并发症的风险。因此，迫切需要开发一种集止血、抗菌和伤口愈合于一体的创新创面敷料。本研究提出了一种基于聚n -异丙基丙烯酰胺（PNIPAM）、壳聚糖（CS）、纳米银修饰氧化石墨烯（GO-Ag NPs）和左氧氟沙星（LVN）的复合多功能水凝胶敷料（GA-CP@LVN）。体外和体内研究表明GA-CP@LVN具有生物相容性、光热性能、高LVN包封效率和缓释性。此外，GA-CP@LVN表现出优越的抗菌和止血功能。值得注意的是，GA-CP@LVN在止血、抑菌和细胞增殖方面表现出强大的协同作用，显著促进了金黄色葡萄球菌感染小鼠模型的伤口愈合。因此，GA-CP@LVN作为一种有前途的新型敷料出现在感染伤口修复中。

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Multi-functional poly(N-isopropylacrylamide)-based hydrogel with hemostasis, antibacterial, and sustained drug release properties for infected wound treatment

Wound infections impede healing, exacerbate discomfort, and risk severe complications. Therefore, it is urgent to develop an innovative wound dressing that combines hemostasis, antibacterial and wound healing. This study presented a composite multifunctional hydrogel dressing (GA-CP@LVN) based on Poly(N-isopropylacrylamide) (PNIPAM), chitosan (CS), silver nanoparticles-modified graphene oxide (GO-Ag NPs), and levofloxacin (LVN). In vitro and in vivo studies demonstrated GA-CP@LVN’s biocompatibility, photothermal properties, high LVN encapsulation efficiency, and sustained release. Moreover, GA-CP@LVN exhibited superior antibacterial and hemostatic functionalities. Notably, GA-CP@LVN showed potent synergy in hemostasis, bacteriostasis, and cell proliferation, significantly enhancing wound healing in S. aureus-infected murine models. Thus, GA-CP@LVN emerges as a promising novel dressing for infected wound repair.

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.