用于疾病建模和药物测试的眼部器官芯片系统的进化:我们现在在哪里?

IF 2.6 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Sara Trujillo
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引用次数: 0

摘要

人口老龄化加剧、数字屏幕的使用、环境因素和睡眠障碍导致了眼科疾病的增加。这使得对更好的眼部模型的需求激增,这些模型更具预测性,可用于识别新的药理靶点。传统的模型不能概括器官水平的功能,并呈现出与人体结构的解剖差异,因此,器官芯片系统已经出现,以解决这些限制。微流体装置的设计是为了提供眼组织所需的分层结构。这是结合扩散梯度和灌注系统的毒理学分析和药物筛选应用的严格调节。结合几个细胞层,运动来模仿眨眼,或者在微流体装置中结合眼类器官是该领域取得的一些进步。本工作回顾了眼微生理系统的进化,并讨论了器官芯片社区可能面临的一些挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Evolution of Ocular Organ-On-Chip Systems for Disease Modelling and Drug Testing: Where are We Now?

Evolution of Ocular Organ-On-Chip Systems for Disease Modelling and Drug Testing: Where are We Now?

Evolution of Ocular Organ-On-Chip Systems for Disease Modelling and Drug Testing: Where are We Now?

Evolution of Ocular Organ-On-Chip Systems for Disease Modelling and Drug Testing: Where are We Now?

Evolution of Ocular Organ-On-Chip Systems for Disease Modelling and Drug Testing: Where are We Now?

Increasing aging population, digital screen use, environmental factors, and sleep disorders have contributed to a rise in ophthalmic diseases. This has soared the demand for better ocular models that are more predictive and can be used to identify new pharmacological targets. Traditional models fail to recapitulate organ-level functionalities and present anatomical differences with human structures, therefore, organ-on-chip systems have emerged to tackle these limitations. Microfluidic devices is engineered to provide the layered structure that the ocular tissues require. This is combined with tight regulation of diffusion gradients and perfusion systems for toxicological analysis and drug screening applications. Incorporation of several cellular layers, motion to mimic blinking, or incorporation of ocular organoids in microfluidic devices are some of the advancements that the field has made. This work reviews the evolution of ocular microphysiological systems and discusses some challenges that could be undertaken by the organ-on-chip community.

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来源期刊
Advanced Therapeutics
Advanced Therapeutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
7.10
自引率
2.20%
发文量
130
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