Abdurrahman Mustafa, Ahmed AlSarori, Hasan Akyıldız, Ismail Cihan Kaya, Gulcihan Guzel Kaya
{"title":"FeS2/WS2异质结构:具有增强光动力效应和抗菌活性的温和光热治疗候选材料","authors":"Abdurrahman Mustafa, Ahmed AlSarori, Hasan Akyıldız, Ismail Cihan Kaya, Gulcihan Guzel Kaya","doi":"10.1002/adtp.202500119","DOIUrl":null,"url":null,"abstract":"<p>FeS<sub>2</sub>, a member of metal chalcogenide semiconductors, is a cheap and available material with distinguishable photothermal activity under light irradiation. However, its photodynamic properties have to be improved for practical phototherapy applications. Therefore, in this study, FeS<sub>2</sub>/WS<sub>2</sub> p-n junctions, comprising varying amounts of WS<sub>2</sub>, are synthesized using the simple hot injection method. Establishment of the heterostructure is verified using X-ray diffraction (XRD), scanning transmission electron microscopy (STEM), energy-dispersive X-ray spectroscopy (EDX), and X-ray photoelectron spectroscopy (XPS) analysis. p-n junction formation is further validated via calculations based on ultraviolet-visible (UV–vis.) spectrophotometer and XPS data. Photothermal and photodynamic properties of the samples are examined considering various aspects. The FeS<sub>2</sub>/WS<sub>2</sub> heterostructure provides a heating response above 50 °C with a high photothermal conversion efficiency of 52.6%. The reactive oxygen species (ROS) formation ability is observed to depend on the material concentration and O<sub>2</sub>•<sup>‾</sup> is determined as the primary reactive oxygen species. The in vitro antibacterial activity of the samples is tested against <i>Staphylococcus aureus</i> (<i>S. aureus</i>) and <i>Escherichia coli</i> (<i>E. coli</i>) bacteria as a function of material concentration. At all concentrations, the FeS<sub>2</sub>/WS<sub>2</sub> heterostructure exhibits higher activity than that of FeS<sub>2</sub> nanoparticles. The efficiency of the sample against <i>S. aureus</i> and <i>E. coli</i> is calculated to be 100% and 99.4% respectively, at a low material concentration of 100 µg mL<sup>−1</sup>.</p>","PeriodicalId":7284,"journal":{"name":"Advanced Therapeutics","volume":"8 9","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"FeS2/WS2 Heterostructure: A Promising Candidate for Mild-Temperature Photothermal Therapy with Enhanced Photodynamic Effect and Antibacterial Activity\",\"authors\":\"Abdurrahman Mustafa, Ahmed AlSarori, Hasan Akyıldız, Ismail Cihan Kaya, Gulcihan Guzel Kaya\",\"doi\":\"10.1002/adtp.202500119\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>FeS<sub>2</sub>, a member of metal chalcogenide semiconductors, is a cheap and available material with distinguishable photothermal activity under light irradiation. However, its photodynamic properties have to be improved for practical phototherapy applications. Therefore, in this study, FeS<sub>2</sub>/WS<sub>2</sub> p-n junctions, comprising varying amounts of WS<sub>2</sub>, are synthesized using the simple hot injection method. Establishment of the heterostructure is verified using X-ray diffraction (XRD), scanning transmission electron microscopy (STEM), energy-dispersive X-ray spectroscopy (EDX), and X-ray photoelectron spectroscopy (XPS) analysis. p-n junction formation is further validated via calculations based on ultraviolet-visible (UV–vis.) spectrophotometer and XPS data. Photothermal and photodynamic properties of the samples are examined considering various aspects. The FeS<sub>2</sub>/WS<sub>2</sub> heterostructure provides a heating response above 50 °C with a high photothermal conversion efficiency of 52.6%. The reactive oxygen species (ROS) formation ability is observed to depend on the material concentration and O<sub>2</sub>•<sup>‾</sup> is determined as the primary reactive oxygen species. The in vitro antibacterial activity of the samples is tested against <i>Staphylococcus aureus</i> (<i>S. aureus</i>) and <i>Escherichia coli</i> (<i>E. coli</i>) bacteria as a function of material concentration. At all concentrations, the FeS<sub>2</sub>/WS<sub>2</sub> heterostructure exhibits higher activity than that of FeS<sub>2</sub> nanoparticles. The efficiency of the sample against <i>S. aureus</i> and <i>E. coli</i> is calculated to be 100% and 99.4% respectively, at a low material concentration of 100 µg mL<sup>−1</sup>.</p>\",\"PeriodicalId\":7284,\"journal\":{\"name\":\"Advanced Therapeutics\",\"volume\":\"8 9\",\"pages\":\"\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-07-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Therapeutics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://advanced.onlinelibrary.wiley.com/doi/10.1002/adtp.202500119\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Therapeutics","FirstCategoryId":"3","ListUrlMain":"https://advanced.onlinelibrary.wiley.com/doi/10.1002/adtp.202500119","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
FeS2/WS2 Heterostructure: A Promising Candidate for Mild-Temperature Photothermal Therapy with Enhanced Photodynamic Effect and Antibacterial Activity
FeS2, a member of metal chalcogenide semiconductors, is a cheap and available material with distinguishable photothermal activity under light irradiation. However, its photodynamic properties have to be improved for practical phototherapy applications. Therefore, in this study, FeS2/WS2 p-n junctions, comprising varying amounts of WS2, are synthesized using the simple hot injection method. Establishment of the heterostructure is verified using X-ray diffraction (XRD), scanning transmission electron microscopy (STEM), energy-dispersive X-ray spectroscopy (EDX), and X-ray photoelectron spectroscopy (XPS) analysis. p-n junction formation is further validated via calculations based on ultraviolet-visible (UV–vis.) spectrophotometer and XPS data. Photothermal and photodynamic properties of the samples are examined considering various aspects. The FeS2/WS2 heterostructure provides a heating response above 50 °C with a high photothermal conversion efficiency of 52.6%. The reactive oxygen species (ROS) formation ability is observed to depend on the material concentration and O2•‾ is determined as the primary reactive oxygen species. The in vitro antibacterial activity of the samples is tested against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) bacteria as a function of material concentration. At all concentrations, the FeS2/WS2 heterostructure exhibits higher activity than that of FeS2 nanoparticles. The efficiency of the sample against S. aureus and E. coli is calculated to be 100% and 99.4% respectively, at a low material concentration of 100 µg mL−1.