3d打印支架促进脊髓类器官形成，用于脊髓损伤（ad . Healthcare Mater. 24/2025）

IF 9.6 2区医学 Q1 ENGINEERING, BIOMEDICAL

Advanced Healthcare Materials Pub Date : 2025-09-18 DOI:10.1002/adhm.70212

Guebum Han, Nicolas S. Lavoie, Nandadevi Patil, Olivia G. Korenfeld, Hyunjun Kim, Manuel Esguerra, Daeha Joung, Michael C. McAlpine, Ann M. Parr

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引用次数: 0

摘要

3D打印支架研究文章(DOI 10.1002/adhm。Ann M. Parr及其同事提出了用区域特异性人类ipsc衍生的脊髓神经祖细胞创建的3d打印类器官支架，用于脊髓损伤修复。支架在大鼠移植后可引导轴突生长，促进神经元成熟，并与宿主组织融合，显著恢复功能。这种创新的方法在未来脊髓损伤的再生治疗中具有很大的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

3D-Printed Scaffolds Promote Enhanced Spinal Organoid Formation for Use in Spinal Cord Injury (Adv. Healthcare Mater. 24/2025)

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3D-Printed Scaffolds Promote Enhanced Spinal Organoid Formation for Use in Spinal Cord Injury (Adv. Healthcare Mater. 24/2025)

3D Printed Scaffold

The Research Article (DOI 10.1002/adhm.202404817) by Ann M. Parr and co-workers presents 3D-printed organoid scaffolds created with regionally specific human iPSC-derived spinal neural progenitor cells for spinal cord injury repair. The scaffolds guide axonal growth, enhance neuronal maturation, and integrate with host tissue after transplantation in rats, leading to significant functional recovery. This innovative approach holds strong potential for future regenerative therapies for spinal cord injury.

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来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.