Dong Min Kang, Nataliia Lukianenko, Ja-Hyun Baik, Yun Kyung Kim, Sungsu Lim
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Front Cover: Pathological Disulfide Bond Crosslinking: Molecular Insights into Amyloidogenesis and Diseases Progression (ChemBioChem 18/2025)
This cover illustrates that disulfide crosslinking between amyloidogenic proteins plays a critical role in stabilizing misfolded protein oligomers and facilitating their aggregation into fibrillar assemblies. These disulfide-linked species evade proteolytic clearance, disrupt cellular proteostasis, and propagate between cells—thereby driving proteinopathy characterized by aberrant protein accumulation and aggregation, as observed in various neurodegenerative disorders. More information can be found in the Review Article by Yun Kyung Kim, Sungsu Lim, and co-workers (DOI: 10.1002/cbic.202500316).
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ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).
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