为什么7-酮胆固醇现在很重要：对其致病和治疗相关性的快速回顾

IF 2.5 2区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Steroid Biochemistry and Molecular Biology Pub Date : 2025-09-18 DOI:10.1016/j.jsbmb.2025.106865

Evelyn Sharon Sukumaran , Arin Natania S

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引用次数: 0

摘要

7-酮胆固醇（7-KC）是通过胆固醇自氧化形成的一种主要的氧甾醇，越来越被认为是衰老和慢性疾病的致病介质。在动脉粥样硬化斑块、阿尔茨海默氏症皮层、老化视网膜和溶酶体贮积障碍中检测到的7-KC积极驱动氧化应激、慢性炎症、细胞器功能障碍和氧化细胞吞噬。这些机制支持其在心血管、神经退行性和代谢病理中的作用。最近的进展强调营养抗氧化剂、药物、微生物生物修复和纳米技术是有前途的治疗途径。认识到7-KC既是一种生物标志物，也是一种治疗靶点，为年龄相关疾病和炎症性疾病的诊断和治疗提供了创新机会。

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Why 7-ketocholesterol matters now: A rapid review of its pathogenic and therapeutic relevance

7-Ketocholesterol (7-KC), a major oxysterol formed through cholesterol autoxidation, is increasingly recognized as a pathogenic mediator in ageing and chronic disease. Detected in atherosclerotic plaques, Alzheimer’s cortex, aged retina, and lysosomal storage disorders, 7-KC actively drives oxidative stress, chronic inflammation, organelle dysfunction, and oxiapoptophagy. These mechanisms underpin its role in cardiovascular, neurodegenerative, and metabolic pathologies. Recent advances highlight nutritional antioxidants, pharmacological agents, microbial bioremediation, and nanotechnology as promising therapeutic avenues. Recognizing 7-KC as both a biomarker and therapeutic target offers opportunities for innovation in diagnostics and treatment of age-related and inflammatory disorders.

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来源期刊

Journal of Steroid Biochemistry and Molecular Biology 生物-内分泌学与代谢

CiteScore

8.60

自引率

2.40%

发文量

113

审稿时长

46 days

期刊介绍： The Journal of Steroid Biochemistry and Molecular Biology is devoted to new experimental and theoretical developments in areas related to steroids including vitamin D, lipids and their metabolomics. The Journal publishes a variety of contributions, including original articles, general and focused reviews, and rapid communications (brief articles of particular interest and clear novelty). Selected cutting-edge topics will be addressed in Special Issues managed by Guest Editors. Special Issues will contain both commissioned reviews and original research papers to provide comprehensive coverage of specific topics, and all submissions will undergo rigorous peer-review prior to publication.