{"title":"基于HJ-DGVTFET的乳腺癌唾液和血清CerbB-2生物标志物检测","authors":"Karthik Nasani , Brinda Bhowmick , Puspa Devi Pukhrambam , Puja Ghosh","doi":"10.1016/j.cjph.2025.09.010","DOIUrl":null,"url":null,"abstract":"<div><div>Breast cancer is a prevalent and potentially life-threatening disease, emphasizing the importance of early detection and monitoring. A key target for the identification of diagnostic bioanalytes is the CerbB-2 bioanalyte (BA), whose overexpression has been linked to aggressive types of breast cancer. In this study, a highly sensitive biosensor based on an In<sub>1−x</sub>Ga<sub>x</sub>As/InP heterojunction Dual Gate Vertical tunnel FET (HJ-DGVTFET) is used to detect the breast cancer bioanalyte, CerbB-2, electrically in serum or saliva. In this work, interface charge modulation effect in HJ-DGVTFETs with integrated nano compatibility biosensors is considered for reliable, precise, and fast recognition of antigens in body fluids using blood serum rather than saliva. The suggested biosensor has a double cavity etched under the double gate structure to immobilize bioanalyte. This enhances the bioanalyte influence on the source-channel tunnelling rate and the electrical parameters of the suggested biosensor. Device sensitivity has been examined for various CerbB-2 concentrations in blood and saliva environments. According to our research, an III-V In<sub>1−x</sub>Ga<sub>x</sub>As/InP hetero junction with mole fraction x factor of 0.47 increases the likelihood of tunnelling. It enhances gate control on channel to get a higher sensitivity and I<sub>ON</sub>/I<sub>OFF</sub> ratio.</div></div>","PeriodicalId":10340,"journal":{"name":"Chinese Journal of Physics","volume":"98 ","pages":"Pages 99-107"},"PeriodicalIF":4.6000,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Nano sense-TFET: HJ-DGVTFET based salivary and serum CerbB-2 biomarker detection for breast cancer\",\"authors\":\"Karthik Nasani , Brinda Bhowmick , Puspa Devi Pukhrambam , Puja Ghosh\",\"doi\":\"10.1016/j.cjph.2025.09.010\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Breast cancer is a prevalent and potentially life-threatening disease, emphasizing the importance of early detection and monitoring. A key target for the identification of diagnostic bioanalytes is the CerbB-2 bioanalyte (BA), whose overexpression has been linked to aggressive types of breast cancer. In this study, a highly sensitive biosensor based on an In<sub>1−x</sub>Ga<sub>x</sub>As/InP heterojunction Dual Gate Vertical tunnel FET (HJ-DGVTFET) is used to detect the breast cancer bioanalyte, CerbB-2, electrically in serum or saliva. In this work, interface charge modulation effect in HJ-DGVTFETs with integrated nano compatibility biosensors is considered for reliable, precise, and fast recognition of antigens in body fluids using blood serum rather than saliva. The suggested biosensor has a double cavity etched under the double gate structure to immobilize bioanalyte. This enhances the bioanalyte influence on the source-channel tunnelling rate and the electrical parameters of the suggested biosensor. Device sensitivity has been examined for various CerbB-2 concentrations in blood and saliva environments. According to our research, an III-V In<sub>1−x</sub>Ga<sub>x</sub>As/InP hetero junction with mole fraction x factor of 0.47 increases the likelihood of tunnelling. It enhances gate control on channel to get a higher sensitivity and I<sub>ON</sub>/I<sub>OFF</sub> ratio.</div></div>\",\"PeriodicalId\":10340,\"journal\":{\"name\":\"Chinese Journal of Physics\",\"volume\":\"98 \",\"pages\":\"Pages 99-107\"},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2025-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chinese Journal of Physics\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0577907325003612\",\"RegionNum\":2,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PHYSICS, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Journal of Physics","FirstCategoryId":"101","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0577907325003612","RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSICS, MULTIDISCIPLINARY","Score":null,"Total":0}
Nano sense-TFET: HJ-DGVTFET based salivary and serum CerbB-2 biomarker detection for breast cancer
Breast cancer is a prevalent and potentially life-threatening disease, emphasizing the importance of early detection and monitoring. A key target for the identification of diagnostic bioanalytes is the CerbB-2 bioanalyte (BA), whose overexpression has been linked to aggressive types of breast cancer. In this study, a highly sensitive biosensor based on an In1−xGaxAs/InP heterojunction Dual Gate Vertical tunnel FET (HJ-DGVTFET) is used to detect the breast cancer bioanalyte, CerbB-2, electrically in serum or saliva. In this work, interface charge modulation effect in HJ-DGVTFETs with integrated nano compatibility biosensors is considered for reliable, precise, and fast recognition of antigens in body fluids using blood serum rather than saliva. The suggested biosensor has a double cavity etched under the double gate structure to immobilize bioanalyte. This enhances the bioanalyte influence on the source-channel tunnelling rate and the electrical parameters of the suggested biosensor. Device sensitivity has been examined for various CerbB-2 concentrations in blood and saliva environments. According to our research, an III-V In1−xGaxAs/InP hetero junction with mole fraction x factor of 0.47 increases the likelihood of tunnelling. It enhances gate control on channel to get a higher sensitivity and ION/IOFF ratio.
期刊介绍:
The Chinese Journal of Physics publishes important advances in various branches in physics, including statistical and biophysical physics, condensed matter physics, atomic/molecular physics, optics, particle physics and nuclear physics.
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