PRRS病毒感染中自噬亚型的分子机制及治疗潜力

IF 2.4 3区医学 Q3 VIROLOGY

Virology Pub Date : 2025-09-18 DOI:10.1016/j.virol.2025.110697

Guang-Wei Zhao , Xin-Feng Li , Guo-Jia Yao , Qiu-Liang Xu

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引用次数: 0

摘要

猪繁殖与呼吸综合征（PRRS）病毒是一种RNA病毒，可导致怀孕母猪繁殖失败和所有年龄猪的呼吸系统疾病。自噬是一种依赖溶酶体的降解过程，包括巨噬、微自噬和伴侣介导的自噬，它们共同维持细胞稳态并影响疾病进展。虽然自噬具有消灭病毒的潜力，但某些病毒可以操纵这一过程来增强自身的复制。本文综述了自噬在PRRS病毒感染中的双重作用，阐明了PRRS发病机制，并提出了以自噬为靶点的抗PRRS病毒干预策略。

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The molecular mechanism and therapeutic potential of autophagy subtypes in PRRS virus infection

Porcine reproductive and respiratory syndrome (PRRS) virus is an RNA virus that causes reproductive failure in pregnant sows and respiratory diseases in pigs of all ages. Autophagy, a lysosome-dependent degradation process, consists of macroautophagy, microautophagy, and chaperone-mediated autophagy, which collectively maintain cellular homeostasis and influence disease progression. Although autophagy has the potential to eliminate viruses, certain viruses can manipulate this process to enhance their own replication. This review discusses the dual role of autophagy in PRRS virus infection, elucidates mechanisms underlying PRRS pathogenesis, and proposes autophagy-targeted strategies for the development of anti-PRRS virus interventions.

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来源期刊

Virology 医学-病毒学

CiteScore

6.00

自引率

0.00%

发文量

157

审稿时长

50 days

期刊介绍： Launched in 1955, Virology is a broad and inclusive journal that welcomes submissions on all aspects of virology including plant, animal, microbial and human viruses. The journal publishes basic research as well as pre-clinical and clinical studies of vaccines, anti-viral drugs and their development, anti-viral therapies, and computational studies of virus infections. Any submission that is of broad interest to the community of virologists/vaccinologists and reporting scientifically accurate and valuable research will be considered for publication, including negative findings and multidisciplinary work.Virology is open to reviews, research manuscripts, short communication, registered reports as well as follow-up manuscripts.