金属钴离子配位增强藻蓝胆素光动力抗癌活性

IF 4.2 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments Pub Date : 2025-09-13 DOI:10.1016/j.dyepig.2025.113242

Zehua Lu , Yuru Yao , Yunquan Zheng , Jianmin Yang , Xianai Shi , Chengqun Chen

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引用次数: 0

摘要

我们的前期研究表明，Arthrospira phycocyanobilin （PCB）是一种具有线性四吡啶结构的天然抗癌光敏剂（PS）。天然来源的PSs对人体无害，与临床PSs相比，其细胞毒性相对较低。如何在保持其生物相容性的同时增强其活性一直是一个挑战，这对于开发天然抗癌ps至关重要。该研究表明，线性四吡啶中过渡金属离子Co2+的中心配位增加了活性氧（ROS）的量子产率，并提高了PCB在光照射后的光动力抗癌活性。Co-PCB的ROS量子产率为0.5109，是PCB（0.1481）的2.45倍。Co-PCB对HeLa细胞的光动力抗癌活性约为PCB的4.48倍（IC50: 10.69±0.50 μM vs. 47.91±0.91 μM）。Zn-phthalocyanine （ZnPc）是第二代PS的代表，Co-PCB具有更高的生物安全性，其抗癌治疗指数比ZnPc高55.14%。多氯联苯在光动力抗癌治疗中具有潜在的应用前景。为开发和应用其他天然线性四吡咯类化合物提供了基础，以提高其活性，同时保持其生物相容性。

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Photodynamic anticancer activity of Arthrospira phycocyanobilin enhanced by metal cobalt ion coordination

Our previous research has demonstrated that Arthrospira phycocyanobilin (PCB) is a natural anticancer photosensitizer (PS) with a linear tetrapyrrole structure. Natural sources of PSs are harmless to the human body and exhibit relatively low cytotoxicity compared to clinical PSs. The challenge has always been to enhance their activity while maintaining their biocompatibility, which is crucial for the development of natural anticancer PSs. This study shows that the central coordination of transition metal ion Co²⁺ in linear tetrapyrroles increases the quantum yield of reactive oxygen species (ROS) and improves the photodynamic anticancer activity of PCB following light exposure. The ROS quantum yield of Co-PCB is 0.5109, which is 2.45 times higher than that of PCB (0.1481). Co-PCB exhibited approximately 4.48 times the photodynamic anticancer activity of PCB on HeLa cells (IC₅₀: 10.69 ± 0.50 μM vs. 47.91 ± 0.91 μM). Zn-phthalocyanine (ZnPc) is a representative second-generation PS. Co-PCB exhibits greater biosafety, while its anticancer therapeutic index is 55.14 % higher than that of ZnPc. Co-PCB has the potential to be used in photodynamic anticancer therapy. Furthermore, it could be used as a basis for developing and applying other natural linear tetrapyrrole compounds to improved their activity while maintaining biocompatibility.

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.