Supramolecular Analysis of Six Novel Multicomponent Compounds of Substituted Salicylic Acids with Pyridine-Based Coformers

Crystallization of salicylic acid derivatives in the presence of either pyridine or 2-aminopyridine produced six novel crystal structures, covering most of the key components of the typical organic crystal form landscape. The six structures, which comprise salts, ionic cocrystals, solvates, and polymorphs, have been structurally compared and the influence of intermolecular interactions and molecular shape have been examined to identify any possible influence on the crystal packing and the energy frameworks of the different crystal forms.

Crystallization of salicylic acid derivatives with pyridine-based coformers yielded a diverse array of crystal forms, including salts, ionic cocrystals, solvates, and polymorphs, highlighting the broad range of outcomes within the organic crystal form landscape and their dependence on intermolecular interactions and molecular shape.