Xue Song, Qingsong Chen, Liuzeng Chen, Banfeng Ruan*, Bin Li* and Xingxing Zhang*,
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Recent Advances in Catalytic Asymmetric Hydrogenation of β-Ketoesters
The catalytic asymmetric reduction of β-ketoesters represents a cornerstone transformation in modern organic synthesis, enabling the production of enantiomerically enriched β-hydroxyesters─critical building blocks in the synthesis of pharmaceuticals, vitamins, and natural products. This review highlights recent advances in the catalytic asymmetric reduction of β-ketoesters, with particular emphasis on the relationship between catalyst architecture and stereochemical outcomes. The discussion encompasses the evolving role of carriers in heterogeneous asymmetric catalysis, and the potential for industrial applications. Furthermore, this review also discussed the current technological limitations and emerging opportunities in the field, providing insights into future directions for research and development.
期刊介绍：
The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.
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