{"title":"室外日光照射时间与原发性开角型青光眼的关系","authors":"Jianqi Chen,Shaofen Huang,Xiaohua Zhuo,Xuhao Chen,Rui Xie,Ruiyu Luo,Xinyue Shen,Yue Xiao,Jingying Liang,Yingting Zhu,Jingfeng Mu,Hongmei Tan,Yehong Zhuo","doi":"10.1016/j.ajo.2025.09.022","DOIUrl":null,"url":null,"abstract":"PURPOSE\r\nAs a crucial environmental factor, outdoor daylight exposure has become an increasing focus in ophthalmic research. Although exploratory studies have indicated a potential connection between daylight exposure and primary open-angle glaucoma (POAG), a detailed association remains largely unknown. This study aimed to examine the association using data from the UK Biobank.\r\n\r\nDESIGN\r\nCombined cross-sectional and cohort study.\r\n\r\nPARTICIPANTS\r\nFollowing the application of exclusion criteria, 67,558 and 71,480 participants were included in the analysis of POAG incidence and prevalence, respectively. Additionally, 69,441 and 28,029 participants were included in the analysis of intraocular pressure (IOP) and ganglion cell complex (GCC) thickness, which are traits related to POAG.\r\n\r\nMETHODS\r\nThe initial assessment of outdoor daylight exposure duration was conducted using a standardized touchscreen questionnaire and measured in hours per day. Cox proportional hazard models were employed to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for each additional hour of exposure per day. Additionally, logistic regression models and linear regression models were utilized to investigate the association with POAG prevalence and POAG-related traits, with adjustments made for multiple covariates.\r\n\r\nMAIN OUTCOME MEASURES\r\nPOAG incidence, prevalence, and related traits.\r\n\r\nRESULTS\r\nAfter adjusting for all covariates, annual average daylight exposure duration (HR, 1.10; 95% CI, 1.02-1.18; P = 0.009) and summer daylight exposure duration (HR, 1.08; 95% CI, 1.02-1.14; P = 0.009) were associated with an increased incidence of POAG, and stronger associations were observed for males. Participants with elevated outdoor exposure duration had higher IOP levels across annual exposure (β, 0.04, 95% CI, 0.03-0.06, P<0.001), summer exposure (β, 0.04, 95% CI, 0.03-0.05, P<0.001), and winter exposure (β = 0.02, 95% CI, 0.01-0.04, P=0.007). No association was found between outdoor daylight exposure and the prevalence of POAG or GCC thickness.\r\n\r\nCONCLUSIONS\r\nProlonged daylight exposure, particularly during the summer, is associated with an elevated risk of POAG incidence, possibly due to increased IOP. These findings highlight the need for protective strategies against excessive daylight exposure.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"316 1","pages":""},"PeriodicalIF":4.2000,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between Outdoor Daylight Exposure Duration and Primary Open-Angle Glaucoma.\",\"authors\":\"Jianqi Chen,Shaofen Huang,Xiaohua Zhuo,Xuhao Chen,Rui Xie,Ruiyu Luo,Xinyue Shen,Yue Xiao,Jingying Liang,Yingting Zhu,Jingfeng Mu,Hongmei Tan,Yehong Zhuo\",\"doi\":\"10.1016/j.ajo.2025.09.022\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"PURPOSE\\r\\nAs a crucial environmental factor, outdoor daylight exposure has become an increasing focus in ophthalmic research. Although exploratory studies have indicated a potential connection between daylight exposure and primary open-angle glaucoma (POAG), a detailed association remains largely unknown. This study aimed to examine the association using data from the UK Biobank.\\r\\n\\r\\nDESIGN\\r\\nCombined cross-sectional and cohort study.\\r\\n\\r\\nPARTICIPANTS\\r\\nFollowing the application of exclusion criteria, 67,558 and 71,480 participants were included in the analysis of POAG incidence and prevalence, respectively. Additionally, 69,441 and 28,029 participants were included in the analysis of intraocular pressure (IOP) and ganglion cell complex (GCC) thickness, which are traits related to POAG.\\r\\n\\r\\nMETHODS\\r\\nThe initial assessment of outdoor daylight exposure duration was conducted using a standardized touchscreen questionnaire and measured in hours per day. Cox proportional hazard models were employed to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for each additional hour of exposure per day. Additionally, logistic regression models and linear regression models were utilized to investigate the association with POAG prevalence and POAG-related traits, with adjustments made for multiple covariates.\\r\\n\\r\\nMAIN OUTCOME MEASURES\\r\\nPOAG incidence, prevalence, and related traits.\\r\\n\\r\\nRESULTS\\r\\nAfter adjusting for all covariates, annual average daylight exposure duration (HR, 1.10; 95% CI, 1.02-1.18; P = 0.009) and summer daylight exposure duration (HR, 1.08; 95% CI, 1.02-1.14; P = 0.009) were associated with an increased incidence of POAG, and stronger associations were observed for males. Participants with elevated outdoor exposure duration had higher IOP levels across annual exposure (β, 0.04, 95% CI, 0.03-0.06, P<0.001), summer exposure (β, 0.04, 95% CI, 0.03-0.05, P<0.001), and winter exposure (β = 0.02, 95% CI, 0.01-0.04, P=0.007). No association was found between outdoor daylight exposure and the prevalence of POAG or GCC thickness.\\r\\n\\r\\nCONCLUSIONS\\r\\nProlonged daylight exposure, particularly during the summer, is associated with an elevated risk of POAG incidence, possibly due to increased IOP. These findings highlight the need for protective strategies against excessive daylight exposure.\",\"PeriodicalId\":7568,\"journal\":{\"name\":\"American Journal of Ophthalmology\",\"volume\":\"316 1\",\"pages\":\"\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2025-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American Journal of Ophthalmology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.ajo.2025.09.022\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ajo.2025.09.022","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Association between Outdoor Daylight Exposure Duration and Primary Open-Angle Glaucoma.
PURPOSE
As a crucial environmental factor, outdoor daylight exposure has become an increasing focus in ophthalmic research. Although exploratory studies have indicated a potential connection between daylight exposure and primary open-angle glaucoma (POAG), a detailed association remains largely unknown. This study aimed to examine the association using data from the UK Biobank.
DESIGN
Combined cross-sectional and cohort study.
PARTICIPANTS
Following the application of exclusion criteria, 67,558 and 71,480 participants were included in the analysis of POAG incidence and prevalence, respectively. Additionally, 69,441 and 28,029 participants were included in the analysis of intraocular pressure (IOP) and ganglion cell complex (GCC) thickness, which are traits related to POAG.
METHODS
The initial assessment of outdoor daylight exposure duration was conducted using a standardized touchscreen questionnaire and measured in hours per day. Cox proportional hazard models were employed to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for each additional hour of exposure per day. Additionally, logistic regression models and linear regression models were utilized to investigate the association with POAG prevalence and POAG-related traits, with adjustments made for multiple covariates.
MAIN OUTCOME MEASURES
POAG incidence, prevalence, and related traits.
RESULTS
After adjusting for all covariates, annual average daylight exposure duration (HR, 1.10; 95% CI, 1.02-1.18; P = 0.009) and summer daylight exposure duration (HR, 1.08; 95% CI, 1.02-1.14; P = 0.009) were associated with an increased incidence of POAG, and stronger associations were observed for males. Participants with elevated outdoor exposure duration had higher IOP levels across annual exposure (β, 0.04, 95% CI, 0.03-0.06, P<0.001), summer exposure (β, 0.04, 95% CI, 0.03-0.05, P<0.001), and winter exposure (β = 0.02, 95% CI, 0.01-0.04, P=0.007). No association was found between outdoor daylight exposure and the prevalence of POAG or GCC thickness.
CONCLUSIONS
Prolonged daylight exposure, particularly during the summer, is associated with an elevated risk of POAG incidence, possibly due to increased IOP. These findings highlight the need for protective strategies against excessive daylight exposure.
期刊介绍:
The American Journal of Ophthalmology is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and visual science specialists describing clinical investigations, clinical observations, and clinically relevant laboratory investigations. Published monthly since 1884, the full text of the American Journal of Ophthalmology and supplementary material are also presented online at www.AJO.com and on ScienceDirect.
The American Journal of Ophthalmology publishes Full-Length Articles, Perspectives, Editorials, Correspondences, Books Reports and Announcements. Brief Reports and Case Reports are no longer published. We recommend submitting Brief Reports and Case Reports to our companion publication, the American Journal of Ophthalmology Case Reports.
Manuscripts are accepted with the understanding that they have not been and will not be published elsewhere substantially in any format, and that there are no ethical problems with the content or data collection. Authors may be requested to produce the data upon which the manuscript is based and to answer expeditiously any questions about the manuscript or its authors.