Rachel S Chong,Bryan Sim,Hla Myint Htoon,Audrey Chia
{"title":"眼部放大矫正对近视儿童黄斑神经节细胞复合体测量的影响。","authors":"Rachel S Chong,Bryan Sim,Hla Myint Htoon,Audrey Chia","doi":"10.1016/j.ajo.2025.09.019","DOIUrl":null,"url":null,"abstract":"PURPOSE\r\nOptical Coherence Tomography (OCT) imaging in myopic eyes may be influenced by measurement error from axial length-induced magnification effects. We studied the effects of magnification correction on ganglion cell complex (GCL++) thickness in myopic children.\r\n\r\nDESIGN\r\nClinical cohort SUBJECTS: Children aged 7-16 years in a myopic clinic METHODS: Data collected included age, gender, race, cycloplegic refraction, axial length (AL), keratometry (K), intraocular pressure (IOP), cup-to-disc ratio (CDR), optic disc tilt, peripapillary atrophy (PPA) and OCT macula scans from the right eye. GCL++ thickness in the central, inner and outer superior, inferior, nasal and temporal quadrants was measured with or without adjustments for ocular magnification using the Littmann-Bennett formula.\r\n\r\nRESULTS\r\n492 subjects, comprising 46.7% male and 91.8% Chinese with an average age of 10.3±1.6 years were included in the study. Mean spherical equivalent (SE) was -4.43±2.24D, and AL was 25.04±1.05 mm. Multivariate analysis showed unadjusted and adjusted GCL++ thickening in older age; in the central and inner quadrants in males; and in the outer temporal quadrant in Chinese children. Central unadjusted and adjusted GCL++ were also thicker with decreased SE, flatter K and increased AL. In other quadrants, unadjusted GCL++ was thinner with decreasing SE and increasing AL in all but the nasal quadrant. Adjusted values were thicker with decreased SE, flatter K, and increasing AL (p≤0.001 for all). IOP, CDR, optic disc tilt, PPA and myopia treatment had no effect on GCL++.\r\n\r\nDISCUSSION\r\nOcular magnification correction of OCT-measured retinal layer thickness using adjustments for axial length suggests increasing myopia is associated with thickening of the ganglion cell complex in children.","PeriodicalId":7568,"journal":{"name":"American Journal of Ophthalmology","volume":"38 1","pages":""},"PeriodicalIF":4.2000,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of Ocular Magnification Correction on Measurements of Macula Ganglion Cell Complex in Myopic Children.\",\"authors\":\"Rachel S Chong,Bryan Sim,Hla Myint Htoon,Audrey Chia\",\"doi\":\"10.1016/j.ajo.2025.09.019\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"PURPOSE\\r\\nOptical Coherence Tomography (OCT) imaging in myopic eyes may be influenced by measurement error from axial length-induced magnification effects. We studied the effects of magnification correction on ganglion cell complex (GCL++) thickness in myopic children.\\r\\n\\r\\nDESIGN\\r\\nClinical cohort SUBJECTS: Children aged 7-16 years in a myopic clinic METHODS: Data collected included age, gender, race, cycloplegic refraction, axial length (AL), keratometry (K), intraocular pressure (IOP), cup-to-disc ratio (CDR), optic disc tilt, peripapillary atrophy (PPA) and OCT macula scans from the right eye. GCL++ thickness in the central, inner and outer superior, inferior, nasal and temporal quadrants was measured with or without adjustments for ocular magnification using the Littmann-Bennett formula.\\r\\n\\r\\nRESULTS\\r\\n492 subjects, comprising 46.7% male and 91.8% Chinese with an average age of 10.3±1.6 years were included in the study. Mean spherical equivalent (SE) was -4.43±2.24D, and AL was 25.04±1.05 mm. Multivariate analysis showed unadjusted and adjusted GCL++ thickening in older age; in the central and inner quadrants in males; and in the outer temporal quadrant in Chinese children. Central unadjusted and adjusted GCL++ were also thicker with decreased SE, flatter K and increased AL. In other quadrants, unadjusted GCL++ was thinner with decreasing SE and increasing AL in all but the nasal quadrant. Adjusted values were thicker with decreased SE, flatter K, and increasing AL (p≤0.001 for all). IOP, CDR, optic disc tilt, PPA and myopia treatment had no effect on GCL++.\\r\\n\\r\\nDISCUSSION\\r\\nOcular magnification correction of OCT-measured retinal layer thickness using adjustments for axial length suggests increasing myopia is associated with thickening of the ganglion cell complex in children.\",\"PeriodicalId\":7568,\"journal\":{\"name\":\"American Journal of Ophthalmology\",\"volume\":\"38 1\",\"pages\":\"\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2025-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American Journal of Ophthalmology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.ajo.2025.09.019\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ajo.2025.09.019","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Effect of Ocular Magnification Correction on Measurements of Macula Ganglion Cell Complex in Myopic Children.
PURPOSE
Optical Coherence Tomography (OCT) imaging in myopic eyes may be influenced by measurement error from axial length-induced magnification effects. We studied the effects of magnification correction on ganglion cell complex (GCL++) thickness in myopic children.
DESIGN
Clinical cohort SUBJECTS: Children aged 7-16 years in a myopic clinic METHODS: Data collected included age, gender, race, cycloplegic refraction, axial length (AL), keratometry (K), intraocular pressure (IOP), cup-to-disc ratio (CDR), optic disc tilt, peripapillary atrophy (PPA) and OCT macula scans from the right eye. GCL++ thickness in the central, inner and outer superior, inferior, nasal and temporal quadrants was measured with or without adjustments for ocular magnification using the Littmann-Bennett formula.
RESULTS
492 subjects, comprising 46.7% male and 91.8% Chinese with an average age of 10.3±1.6 years were included in the study. Mean spherical equivalent (SE) was -4.43±2.24D, and AL was 25.04±1.05 mm. Multivariate analysis showed unadjusted and adjusted GCL++ thickening in older age; in the central and inner quadrants in males; and in the outer temporal quadrant in Chinese children. Central unadjusted and adjusted GCL++ were also thicker with decreased SE, flatter K and increased AL. In other quadrants, unadjusted GCL++ was thinner with decreasing SE and increasing AL in all but the nasal quadrant. Adjusted values were thicker with decreased SE, flatter K, and increasing AL (p≤0.001 for all). IOP, CDR, optic disc tilt, PPA and myopia treatment had no effect on GCL++.
DISCUSSION
Ocular magnification correction of OCT-measured retinal layer thickness using adjustments for axial length suggests increasing myopia is associated with thickening of the ganglion cell complex in children.
期刊介绍:
The American Journal of Ophthalmology is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and visual science specialists describing clinical investigations, clinical observations, and clinically relevant laboratory investigations. Published monthly since 1884, the full text of the American Journal of Ophthalmology and supplementary material are also presented online at www.AJO.com and on ScienceDirect.
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Manuscripts are accepted with the understanding that they have not been and will not be published elsewhere substantially in any format, and that there are no ethical problems with the content or data collection. Authors may be requested to produce the data upon which the manuscript is based and to answer expeditiously any questions about the manuscript or its authors.