Virginia Delucchi, Matteo Lambertini, Eva Blondeaux
{"title":"响应：年轻BRCA1携带者乳腺癌降低风险乳房切除术后的生存率。","authors":"Virginia Delucchi, Matteo Lambertini, Eva Blondeaux","doi":"10.1038/s44276-025-00179-6","DOIUrl":null,"url":null,"abstract":"<p><p>We address methodological considerations in evaluating risk-reducing mastectomy among young BRCA carriers with prior history of breast cancer, emphasizing time-dependent analysis, realistic assumptions on mortality and contralateral breast cancer risk, and appropriate confounder adjustment as ways to improve accuracy in survival outcome estimates.</p>","PeriodicalId":519964,"journal":{"name":"BJC reports","volume":"3 1","pages":"62"},"PeriodicalIF":0.0000,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449466/pdf/","citationCount":"0","resultStr":"{\"title\":\"Response to: Survival after risk-reducing mastectomy in young BRCA1 carriers with breast cancer.\",\"authors\":\"Virginia Delucchi, Matteo Lambertini, Eva Blondeaux\",\"doi\":\"10.1038/s44276-025-00179-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We address methodological considerations in evaluating risk-reducing mastectomy among young BRCA carriers with prior history of breast cancer, emphasizing time-dependent analysis, realistic assumptions on mortality and contralateral breast cancer risk, and appropriate confounder adjustment as ways to improve accuracy in survival outcome estimates.</p>\",\"PeriodicalId\":519964,\"journal\":{\"name\":\"BJC reports\",\"volume\":\"3 1\",\"pages\":\"62\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-09-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449466/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BJC reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1038/s44276-025-00179-6\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BJC reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s44276-025-00179-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Response to: Survival after risk-reducing mastectomy in young BRCA1 carriers with breast cancer.
We address methodological considerations in evaluating risk-reducing mastectomy among young BRCA carriers with prior history of breast cancer, emphasizing time-dependent analysis, realistic assumptions on mortality and contralateral breast cancer risk, and appropriate confounder adjustment as ways to improve accuracy in survival outcome estimates.
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