Quinn Goddard , Gilaad G. Kaplan , Stephanie Coward , Tyler Williamson , Scott Patten , Marcia Bruce , Jenny Godley , Rita Henderson , Tara A. Whitten , Araba Chintoh , James A. King
{"title":"乳糜泻自身免疫事件后精神病药物的使用增加。","authors":"Quinn Goddard , Gilaad G. Kaplan , Stephanie Coward , Tyler Williamson , Scott Patten , Marcia Bruce , Jenny Godley , Rita Henderson , Tara A. Whitten , Araba Chintoh , James A. King","doi":"10.1016/j.jpsychores.2025.112377","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Celiac disease is associated with an increased risk of psychiatric disorders, yet little is known about formal treatment for such conditions among patients.</div></div><div><h3>Methods</h3><div>Using administrative healthcare data, we conducted a population-based cohort study of individuals newly positive for celiac autoimmunity (tTG) between 2015 and 2023 in Alberta, Canada. Individuals were linked to medication dispensations to assess use of antidepressants, anxiolytics, and antipsychotics. We calculated the proportion of days covered (PDC) by psychiatric medication as the number of days for which medication was prescribed. We conducted identical sub-analyses for individuals with anxiety and/or depression-related healthcare encounters prior to their positive tTG test.</div></div><div><h3>Results</h3><div>Among 14,323 newly tTG-positive individuals, a greater proportion dispensed antidepressants (22.5 % vs 27.6 %) and antipsychotics (4.6 % vs 6.0 %) post-tTG, while a lower proportion dispensed anxiolytics post-tTG (15.4 % vs 11.4 %), all <em>p</em> < 0.001. We observed higher odds of being dispensed psychiatric medication post-tTG (OR = 1.22; 95 % CI = 1.14, 1.31). Median PDC also significantly increased post-tTG test for antidepressants (2.8 % vs 21.1 %) and antipsychotics (0.4 % vs 6.3 %), <em>p</em> < 0.001. However, a decreased odds of medication dispensation (OR = 0.42; 95 % CI: 0.32, 0.56) and median PDC post-tTG (45.1 % vs. 10.1 %, <em>p</em> < 0.001) were observed among those with a previous depression/anxiety-related healthcare encounter.</div></div><div><h3>Conclusion</h3><div>These findings highlight a need for increased screening for and/or monitoring of psychiatric comorbidities in the celiac population, and further investigation into what may be underpinning greater use of psychiatric medications after tTG positivity.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"198 ","pages":"Article 112377"},"PeriodicalIF":3.3000,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Increased use of psychiatric medication following incident celiac autoimmunity\",\"authors\":\"Quinn Goddard , Gilaad G. Kaplan , Stephanie Coward , Tyler Williamson , Scott Patten , Marcia Bruce , Jenny Godley , Rita Henderson , Tara A. Whitten , Araba Chintoh , James A. King\",\"doi\":\"10.1016/j.jpsychores.2025.112377\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Celiac disease is associated with an increased risk of psychiatric disorders, yet little is known about formal treatment for such conditions among patients.</div></div><div><h3>Methods</h3><div>Using administrative healthcare data, we conducted a population-based cohort study of individuals newly positive for celiac autoimmunity (tTG) between 2015 and 2023 in Alberta, Canada. Individuals were linked to medication dispensations to assess use of antidepressants, anxiolytics, and antipsychotics. We calculated the proportion of days covered (PDC) by psychiatric medication as the number of days for which medication was prescribed. We conducted identical sub-analyses for individuals with anxiety and/or depression-related healthcare encounters prior to their positive tTG test.</div></div><div><h3>Results</h3><div>Among 14,323 newly tTG-positive individuals, a greater proportion dispensed antidepressants (22.5 % vs 27.6 %) and antipsychotics (4.6 % vs 6.0 %) post-tTG, while a lower proportion dispensed anxiolytics post-tTG (15.4 % vs 11.4 %), all <em>p</em> < 0.001. We observed higher odds of being dispensed psychiatric medication post-tTG (OR = 1.22; 95 % CI = 1.14, 1.31). Median PDC also significantly increased post-tTG test for antidepressants (2.8 % vs 21.1 %) and antipsychotics (0.4 % vs 6.3 %), <em>p</em> < 0.001. However, a decreased odds of medication dispensation (OR = 0.42; 95 % CI: 0.32, 0.56) and median PDC post-tTG (45.1 % vs. 10.1 %, <em>p</em> < 0.001) were observed among those with a previous depression/anxiety-related healthcare encounter.</div></div><div><h3>Conclusion</h3><div>These findings highlight a need for increased screening for and/or monitoring of psychiatric comorbidities in the celiac population, and further investigation into what may be underpinning greater use of psychiatric medications after tTG positivity.</div></div>\",\"PeriodicalId\":50074,\"journal\":{\"name\":\"Journal of Psychosomatic Research\",\"volume\":\"198 \",\"pages\":\"Article 112377\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-09-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Psychosomatic Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0022399925003411\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Psychosomatic Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022399925003411","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Increased use of psychiatric medication following incident celiac autoimmunity
Background
Celiac disease is associated with an increased risk of psychiatric disorders, yet little is known about formal treatment for such conditions among patients.
Methods
Using administrative healthcare data, we conducted a population-based cohort study of individuals newly positive for celiac autoimmunity (tTG) between 2015 and 2023 in Alberta, Canada. Individuals were linked to medication dispensations to assess use of antidepressants, anxiolytics, and antipsychotics. We calculated the proportion of days covered (PDC) by psychiatric medication as the number of days for which medication was prescribed. We conducted identical sub-analyses for individuals with anxiety and/or depression-related healthcare encounters prior to their positive tTG test.
Results
Among 14,323 newly tTG-positive individuals, a greater proportion dispensed antidepressants (22.5 % vs 27.6 %) and antipsychotics (4.6 % vs 6.0 %) post-tTG, while a lower proportion dispensed anxiolytics post-tTG (15.4 % vs 11.4 %), all p < 0.001. We observed higher odds of being dispensed psychiatric medication post-tTG (OR = 1.22; 95 % CI = 1.14, 1.31). Median PDC also significantly increased post-tTG test for antidepressants (2.8 % vs 21.1 %) and antipsychotics (0.4 % vs 6.3 %), p < 0.001. However, a decreased odds of medication dispensation (OR = 0.42; 95 % CI: 0.32, 0.56) and median PDC post-tTG (45.1 % vs. 10.1 %, p < 0.001) were observed among those with a previous depression/anxiety-related healthcare encounter.
Conclusion
These findings highlight a need for increased screening for and/or monitoring of psychiatric comorbidities in the celiac population, and further investigation into what may be underpinning greater use of psychiatric medications after tTG positivity.
期刊介绍:
The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.