Transforming neonatal care through informatics: A review of artificial intelligence, data, and implementation considerations.

Significant strides have been made in utilizing data, information, and knowledge to enhance neonatal outcomes. This review examines how data informatics, encompassing electronic health records (EHRs), data standards, and artificial intelligence (AI), has facilitated advancements in neonatal care and research. Vast amounts of data, structured and unstructured, have been produced from clinical care. In turn AI stands to improve patient care, safety, and quality improvement initiatives. Facilitated by AI, clinicians' interaction with neonatal informatic tools is transitioning from reactive to real-time, proactive care. Historically, necrotizing enterocolitis, sepsis, medical imaging, and neonatal mortality have been the targets of AI-integrated neonatal care. While much progress has been made in developing state-of-the-art AI tools, their development and implementation must consider optimization of patient care, clinical workflows, and aim to decrease clinician burnout. Employing a sociotechnical framework to assess both technical and human factors is key to effectively evaluating clinical utility, promoting adoption, and facilitating successful deployment. Beyond technical concerns, ethical considerations such as trust in AI, data security, and model transparency are critical to the responsible deployment of informatics tools. Ongoing advancements in neonatal care coupled with informatics, multi-omics, AI, and federated learning expands the possibilities of personalized care for neonates.