Anne Birgitte Simonsen, Thomas Rustemeyer, Suzana Ljubojevicé Hadzavdic, Radoslaw Spiewak, Anna Belloni Fortina, Margarida Gonçalo, Ana Maria Giménez Arnau, Nidia Planella-Fontanillas, Marie L A Schuttelaar, Heinrich Dickel, Jonathan White, Györgyi Pónyai, S Mark Wilkinson, Esen Özkaya, Ella Dendooven, Nives Pustišek, Jeanne Duus Johansen, Olivier Aerts
{"title":"欧洲儿童接触性过敏：儿科欧洲基线系列的建议。","authors":"Anne Birgitte Simonsen, Thomas Rustemeyer, Suzana Ljubojevicé Hadzavdic, Radoslaw Spiewak, Anna Belloni Fortina, Margarida Gonçalo, Ana Maria Giménez Arnau, Nidia Planella-Fontanillas, Marie L A Schuttelaar, Heinrich Dickel, Jonathan White, Györgyi Pónyai, S Mark Wilkinson, Esen Özkaya, Ella Dendooven, Nives Pustišek, Jeanne Duus Johansen, Olivier Aerts","doi":"10.1111/cod.70033","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Contact allergy is common in children, but no paediatric baseline series (pEBS) exists in Europe, despite recommendations in several countries.</p><p><strong>Objectives: </strong>To collect and compare patch testing data from European centres to propose a common pEBS, possibly adapted by age group.</p><p><strong>Materials and methods: </strong>Data from 13 centres in 12 European countries were aggregated, covering 1816 children (1099 girls, 60.5%), aged 0-16 years, tested with the adult EBS (aEBS) and other frequent allergens between 2018 and 2022. Allergen selection followed adult criteria, with a stricter cut-off for inclusion, requiring at least 1% positive reactions (lower 95% CI) in children.</p><p><strong>Results: </strong>A total of 17 allergens from the aEBS caused positive reactions in ≥ 1% of children (lower 95% CI). Common allergens included metals, fragrances, and preservatives. Tixocortol-21-pivalate was included despite its lower frequency due to its difficult-to-suspect nature. Additional frequent allergens were hydroperoxides of limonene and linalool, Amerchol L-101, and sorbitan sesquioleate. In total, 18 allergens were identified as potentially qualifying for a pEBS, with a further 7 as recommended additions.</p><p><strong>Conclusion: </strong>Results from patch testing children across europe highlight a common set of frequent allergens, which should be considered for a pEBS.</p>","PeriodicalId":10527,"journal":{"name":"Contact Dermatitis","volume":" ","pages":""},"PeriodicalIF":4.6000,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Contact Allergy in Children in Europe: A Proposal for a Paediatric European Baseline Series.\",\"authors\":\"Anne Birgitte Simonsen, Thomas Rustemeyer, Suzana Ljubojevicé Hadzavdic, Radoslaw Spiewak, Anna Belloni Fortina, Margarida Gonçalo, Ana Maria Giménez Arnau, Nidia Planella-Fontanillas, Marie L A Schuttelaar, Heinrich Dickel, Jonathan White, Györgyi Pónyai, S Mark Wilkinson, Esen Özkaya, Ella Dendooven, Nives Pustišek, Jeanne Duus Johansen, Olivier Aerts\",\"doi\":\"10.1111/cod.70033\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Contact allergy is common in children, but no paediatric baseline series (pEBS) exists in Europe, despite recommendations in several countries.</p><p><strong>Objectives: </strong>To collect and compare patch testing data from European centres to propose a common pEBS, possibly adapted by age group.</p><p><strong>Materials and methods: </strong>Data from 13 centres in 12 European countries were aggregated, covering 1816 children (1099 girls, 60.5%), aged 0-16 years, tested with the adult EBS (aEBS) and other frequent allergens between 2018 and 2022. Allergen selection followed adult criteria, with a stricter cut-off for inclusion, requiring at least 1% positive reactions (lower 95% CI) in children.</p><p><strong>Results: </strong>A total of 17 allergens from the aEBS caused positive reactions in ≥ 1% of children (lower 95% CI). Common allergens included metals, fragrances, and preservatives. Tixocortol-21-pivalate was included despite its lower frequency due to its difficult-to-suspect nature. Additional frequent allergens were hydroperoxides of limonene and linalool, Amerchol L-101, and sorbitan sesquioleate. In total, 18 allergens were identified as potentially qualifying for a pEBS, with a further 7 as recommended additions.</p><p><strong>Conclusion: </strong>Results from patch testing children across europe highlight a common set of frequent allergens, which should be considered for a pEBS.</p>\",\"PeriodicalId\":10527,\"journal\":{\"name\":\"Contact Dermatitis\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2025-09-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Contact Dermatitis\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/cod.70033\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ALLERGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Contact Dermatitis","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/cod.70033","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ALLERGY","Score":null,"Total":0}
Contact Allergy in Children in Europe: A Proposal for a Paediatric European Baseline Series.
Background: Contact allergy is common in children, but no paediatric baseline series (pEBS) exists in Europe, despite recommendations in several countries.
Objectives: To collect and compare patch testing data from European centres to propose a common pEBS, possibly adapted by age group.
Materials and methods: Data from 13 centres in 12 European countries were aggregated, covering 1816 children (1099 girls, 60.5%), aged 0-16 years, tested with the adult EBS (aEBS) and other frequent allergens between 2018 and 2022. Allergen selection followed adult criteria, with a stricter cut-off for inclusion, requiring at least 1% positive reactions (lower 95% CI) in children.
Results: A total of 17 allergens from the aEBS caused positive reactions in ≥ 1% of children (lower 95% CI). Common allergens included metals, fragrances, and preservatives. Tixocortol-21-pivalate was included despite its lower frequency due to its difficult-to-suspect nature. Additional frequent allergens were hydroperoxides of limonene and linalool, Amerchol L-101, and sorbitan sesquioleate. In total, 18 allergens were identified as potentially qualifying for a pEBS, with a further 7 as recommended additions.
Conclusion: Results from patch testing children across europe highlight a common set of frequent allergens, which should be considered for a pEBS.
期刊介绍：
Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".
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