啮齿动物和灵长类动物施拉芬基因的循环进化创新。

IF 2.8 2区 生物学 Q2 EVOLUTIONARY BIOLOGY
Joris Mordier, Marine Fraisse, Michel Cohen-Tannoudji, Antoine Molaro
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引用次数: 0

摘要

SCHLAFEN蛋白是rnase相关的一个大家族,具有重要的免疫和发育功能。尽管有这些重要的作用,施拉芬基因在哺乳动物中表现出不同程度的进化保守性。虽然这似乎影响了它们的分子活动,但对这些进化创新的详细了解仍然缺乏。在这里,我们使用深入的系统基因组方法来表征进化轨迹和选择力量塑造哺乳动物Schlafen基因。我们追踪了谱系特异性Schlafen扩增,发现最近的重复在不同的选择力下进化,支持重复的亚功能化周期。在灵长类动物和啮齿类动物的密码子水平的自然选择分析中,发现了参与病毒相互作用的Schlafen蛋白域的反复正选择。结合已知的晶体和预测的蛋白质结构,我们发现了一类新的快速进化的残基富集在SCHLAFEN蛋白二聚体的接触界面上。我们的研究结果表明,SCHLAFEN之间的相容性受到强大的选择压力,并可能影响它们的分子功能。我们假设,与病原体的遗传冲突循环以及同类之间的遗传冲突驱动了施拉芬斯在哺乳动物中反复出现的进化创新。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recurrent Evolutionary Innovations in Rodent and Primate Schlafen Genes.

SCHLAFEN proteins are a large family of RNase-related enzymes carrying essential immune and developmental functions. Despite these important roles, Schlafen genes display varying degrees of evolutionary conservation in mammals. While this appears to influence their molecular activities, a detailed understanding of these evolutionary innovations is still lacking. Here, we used in-depth phylogenomic approaches to characterize the evolutionary trajectories and selective forces shaping mammalian Schlafen genes. We traced lineage-specific Schlafen amplifications and found that recent duplicates evolved under distinct selective forces, supporting repeated subfunctionalization cycles. Codon-level natural selection analyses in primates and rodents identified recurrent positive selection over Schlafen protein domains engaged in viral interactions. Combining known crystal structures and predicted protein structures, we discovered a novel class of rapidly evolving residues enriched at the contact interface of SCHLAFEN protein dimers. Our results suggest that inter-SCHLAFEN compatibilities are under strong selective pressures and are likely to impact their molecular functions. We posit that cycles of genetic conflicts with pathogens and between paralogs drove Schlafens' recurrent evolutionary innovations in mammals.

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来源期刊
Genome Biology and Evolution
Genome Biology and Evolution EVOLUTIONARY BIOLOGY-GENETICS & HEREDITY
CiteScore
5.80
自引率
6.10%
发文量
169
审稿时长
1 months
期刊介绍: About the journal Genome Biology and Evolution (GBE) publishes leading original research at the interface between evolutionary biology and genomics. Papers considered for publication report novel evolutionary findings that concern natural genome diversity, population genomics, the structure, function, organisation and expression of genomes, comparative genomics, proteomics, and environmental genomic interactions. Major evolutionary insights from the fields of computational biology, structural biology, developmental biology, and cell biology are also considered, as are theoretical advances in the field of genome evolution. GBE’s scope embraces genome-wide evolutionary investigations at all taxonomic levels and for all forms of life — within populations or across domains. Its aims are to further the understanding of genomes in their evolutionary context and further the understanding of evolution from a genome-wide perspective.
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