{"title":"运动对超重或肥胖MASLD患者身体成分、健康和血压的影响：一项系统回顾和荟萃分析","authors":"Jiu Chen, Peng Gong, Jun Xie","doi":"10.1016/j.dld.2025.08.090","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To systematically evaluate the effects of exercise on body composition, cardiorespiratory fitness, and blood pressure in overweight or obese patients with metabolic dysfunction-associated steatotic liver disease (MASLD), to provide evidence-based guidance for individualized exercise prescription.</p><p><strong>Methods: </strong>A systematic search was conducted in PubMed, Embase, the Cochrane Library, and Web of Science for randomized controlled trials published from database inception to April 2025. Eligible studies included overweight or obese patients with MASLD, and the intervention consisted of various types of exercise training. The primary outcome measures included body mass index (BMI), body fat percentage, waist circumference, maximal oxygen uptake (VO₂ max), systolic blood pressure (SBP), and diastolic blood pressure (DBP). Meta-analysis was performed using Review Manager version 5.4 and Stata version 16.</p><p><strong>Results: </strong>A total of 26 articles comprising 29 studies and 1123 participants were included. The meta-analysis showed that, exercise interventions were associated with a significant reduction in BMI (SMD = -0.28, P = 0.000) and waist circumference (SMD = -0.41, P = 0.000), while the reduction in body fat percentage did not reach statistical significance (SMD = -0.25, P = 0.061). Regarding blood pressure, exercise significantly decreased DBP (SMD = -0.38, P = 0.000), while the decrease in SBP showed a non-significant trend toward reduction (SMD = -0.26, P = 0.071). In terms of cardiorespiratory fitness, exercise interventions significantly improved VO₂ max (SMD = 0.75, P = 0.000), indicating a notable enhancement in cardiovascular function.</p><p><strong>Conclusion: </strong>Exercise interventions have a positive impact on body composition, cardiorespiratory fitness, and blood pressure in overweight or obese patients with MASLD. The most pronounced effects were observed in the improvement of VO₂ max, waist circumference, and DBP.</p>","PeriodicalId":11268,"journal":{"name":"Digestive and Liver Disease","volume":" ","pages":""},"PeriodicalIF":3.8000,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of exercise on body composition, fitness, and blood pressure in overweight or obese patients with MASLD: A systematic review and meta-analysis.\",\"authors\":\"Jiu Chen, Peng Gong, Jun Xie\",\"doi\":\"10.1016/j.dld.2025.08.090\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To systematically evaluate the effects of exercise on body composition, cardiorespiratory fitness, and blood pressure in overweight or obese patients with metabolic dysfunction-associated steatotic liver disease (MASLD), to provide evidence-based guidance for individualized exercise prescription.</p><p><strong>Methods: </strong>A systematic search was conducted in PubMed, Embase, the Cochrane Library, and Web of Science for randomized controlled trials published from database inception to April 2025. Eligible studies included overweight or obese patients with MASLD, and the intervention consisted of various types of exercise training. The primary outcome measures included body mass index (BMI), body fat percentage, waist circumference, maximal oxygen uptake (VO₂ max), systolic blood pressure (SBP), and diastolic blood pressure (DBP). Meta-analysis was performed using Review Manager version 5.4 and Stata version 16.</p><p><strong>Results: </strong>A total of 26 articles comprising 29 studies and 1123 participants were included. The meta-analysis showed that, exercise interventions were associated with a significant reduction in BMI (SMD = -0.28, P = 0.000) and waist circumference (SMD = -0.41, P = 0.000), while the reduction in body fat percentage did not reach statistical significance (SMD = -0.25, P = 0.061). Regarding blood pressure, exercise significantly decreased DBP (SMD = -0.38, P = 0.000), while the decrease in SBP showed a non-significant trend toward reduction (SMD = -0.26, P = 0.071). In terms of cardiorespiratory fitness, exercise interventions significantly improved VO₂ max (SMD = 0.75, P = 0.000), indicating a notable enhancement in cardiovascular function.</p><p><strong>Conclusion: </strong>Exercise interventions have a positive impact on body composition, cardiorespiratory fitness, and blood pressure in overweight or obese patients with MASLD. The most pronounced effects were observed in the improvement of VO₂ max, waist circumference, and DBP.</p>\",\"PeriodicalId\":11268,\"journal\":{\"name\":\"Digestive and Liver Disease\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2025-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Digestive and Liver Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.dld.2025.08.090\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Digestive and Liver Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.dld.2025.08.090","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
目的：系统评价运动对超重或肥胖合并代谢功能障碍相关脂肪变性肝病（MASLD）患者体成分、心肺功能和血压的影响，为个体化运动处方提供循证指导。方法：系统检索PubMed、Embase、Cochrane图书馆和Web of Science，检索从数据库建立到2025年4月发表的随机对照试验。符合条件的研究包括超重或肥胖的MASLD患者，干预包括各种类型的运动训练。主要结局指标包括体重指数（BMI）、体脂率、腰围、最大摄氧量（vo2max）、收缩压（SBP）和舒张压（DBP）。meta分析使用Review Manager版本5.4和Stata版本16进行。结果：共纳入26篇文章，29项研究，1123名受试者。meta分析显示，运动干预与BMI （SMD = -0.28, P = 0.000）和腰围（SMD = -0.41, P = 0.000）的降低相关，而体脂率的降低无统计学意义（SMD = -0.25, P = 0.061）。在血压方面，运动可显著降低舒张压（SMD = -0.38, P = 0.000），而收缩压的降低无显著趋势（SMD = -0.26, P = 0.071）。在心肺适能方面，运动干预显著提高了VO₂max (SMD = 0.75, P = 0.000)，表明心血管功能显著增强。结论：运动干预对超重或肥胖MASLD患者的体成分、心肺健康和血压有积极影响。最显著的效果是VO 2 max、腰围和DBP的改善。
Effects of exercise on body composition, fitness, and blood pressure in overweight or obese patients with MASLD: A systematic review and meta-analysis.
Objective: To systematically evaluate the effects of exercise on body composition, cardiorespiratory fitness, and blood pressure in overweight or obese patients with metabolic dysfunction-associated steatotic liver disease (MASLD), to provide evidence-based guidance for individualized exercise prescription.
Methods: A systematic search was conducted in PubMed, Embase, the Cochrane Library, and Web of Science for randomized controlled trials published from database inception to April 2025. Eligible studies included overweight or obese patients with MASLD, and the intervention consisted of various types of exercise training. The primary outcome measures included body mass index (BMI), body fat percentage, waist circumference, maximal oxygen uptake (VO₂ max), systolic blood pressure (SBP), and diastolic blood pressure (DBP). Meta-analysis was performed using Review Manager version 5.4 and Stata version 16.
Results: A total of 26 articles comprising 29 studies and 1123 participants were included. The meta-analysis showed that, exercise interventions were associated with a significant reduction in BMI (SMD = -0.28, P = 0.000) and waist circumference (SMD = -0.41, P = 0.000), while the reduction in body fat percentage did not reach statistical significance (SMD = -0.25, P = 0.061). Regarding blood pressure, exercise significantly decreased DBP (SMD = -0.38, P = 0.000), while the decrease in SBP showed a non-significant trend toward reduction (SMD = -0.26, P = 0.071). In terms of cardiorespiratory fitness, exercise interventions significantly improved VO₂ max (SMD = 0.75, P = 0.000), indicating a notable enhancement in cardiovascular function.
Conclusion: Exercise interventions have a positive impact on body composition, cardiorespiratory fitness, and blood pressure in overweight or obese patients with MASLD. The most pronounced effects were observed in the improvement of VO₂ max, waist circumference, and DBP.
期刊介绍：
Digestive and Liver Disease is an international journal of Gastroenterology and Hepatology. It is the official journal of Italian Association for the Study of the Liver (AISF); Italian Association for the Study of the Pancreas (AISP); Italian Association for Digestive Endoscopy (SIED); Italian Association for Hospital Gastroenterologists and Digestive Endoscopists (AIGO); Italian Society of Gastroenterology (SIGE); Italian Society of Pediatric Gastroenterology and Hepatology (SIGENP) and Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD).
Digestive and Liver Disease publishes papers on basic and clinical research in the field of gastroenterology and hepatology.
Contributions consist of:
Original Papers
Correspondence to the Editor
Editorials, Reviews and Special Articles
Progress Reports
Image of the Month
Congress Proceedings
Symposia and Mini-symposia.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
