侵袭性真菌感染是新疗法的并发症。

IF 22.1 1区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Annual review of medicine Pub Date : 2025-09-19 DOI:10.1146/annurev-med-050124-122000

Joseph Pechacek, Michail S Lionakis

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引用次数: 0

摘要

单克隆抗体和小分子激酶抑制剂形式的新型生物疗法已经改变了几种自身免疫性、炎症性和肿瘤性疾病的治疗。然而，其中一些生物制剂会产生复杂的免疫缺陷状态，从而增加机会性感染的风险，包括侵袭性真菌感染（IFIs）。在这篇重点综述中，我们概述了新型生物制剂带来的抗真菌免疫缺陷，并讨论了它们易导致的ifi。更好地了解被生物制剂破坏的免疫途径及其促进的IFI敏感性，应有助于改善接受生物制剂的患者IFI的预防、诊断和治疗。

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Invasive Fungal Infections as a Complication of New Therapies.

Novel biologic therapies in the form of monoclonal antibodies and small molecule kinase inhibitors have transformed the management of several autoimmune, inflammatory, and neoplastic diseases. However, some of these biologics produce complex immunodeficiency states that heighten the risk of opportunistic infections, including invasive fungal infections (IFIs). In this focused review, we outline the antifungal immune defects conferred by novel biologics and discuss the IFIs they predispose to. A better understanding of the immune pathways disrupted by biologics and the IFI susceptibilities they promote should help improve prophylaxis, diagnosis, and treatment for IFIs in patients receiving biologic agents.

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来源期刊

Annual review of medicine 医学-医学：内科

CiteScore

24.90

自引率

0.00%

发文量

期刊介绍： The Annual Review of Medicine, which has been published since 1950, focuses on important advancements in diverse areas of medicine. These include AIDS/HIV, cardiology, clinical pharmacology, dermatology, endocrinology/metabolism, gastroenterology, genetics, immunology, infectious disease, neurology, oncology/hematology, pediatrics, psychiatry, pulmonology, reproductive medicine, and surgery. The journal's current volume has transitioned from a gated access model to an open access model through the Annual Reviews' Subscribe to Open program. All articles published in the journal are now available under a CC BY license.