用于软骨再生的工程多糖支架：机制、功能化和临床前景。

IF 5.6 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-09-08 DOI:10.1016/j.colsurfb.2025.115134

Binglun Zhang , Meng Zhang , Chao Jiang , Wei Yan , Yilong Pan , Fanhe Meng

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引用次数: 0

摘要

多糖是一种天然存在的长链碳水化合物，由糖苷键连接的重复单糖单位组成，由于其生物相容性、生物可降解性和模仿天然细胞外基质的能力，已成为软骨组织工程中有前途的生物材料。本文综述了壳聚糖、海藻酸盐、透明质酸（HA）和硫酸软骨素等多糖在软骨修复中的作用，重点介绍了它们在支架设计、细胞分化和力学性能增强方面的应用。多糖基支架支持软骨形成，调节炎症，促进组织再生，使其成为软骨修复的理想候选材料。抗菌药物和生物活性分子的功能化进一步提高了其预防感染和促进细胞附着和分化的功效。然而，与可扩展性、生物相容性、体内稳定性和成本效益相关的挑战仍然存在。该综述还讨论了新兴趋势，包括3D生物打印、纳米材料和联合疗法的整合，以增强软骨修复的多糖支架。多糖基支架的未来在推进软骨组织工程走向临床应用方面具有很大的前景。

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Engineered polysaccharide scaffolds for cartilage regeneration: Mechanisms, functionalization, and clinical prospects

Polysaccharides, naturally occurring long-chain carbohydrates composed of repeated monosaccharide units linked by glycosidic bonds, have emerged as promising biomaterials for cartilage tissue engineering due to their biocompatibility, biodegradability, and ability to mimic the natural extracellular matrix. This review explores the roles of polysaccharides, such as chitosan, alginate, hyaluronic acid (HA), and chondroitin sulfate, in cartilage repair, focusing on their applications in scaffold design, cell differentiation, and mechanical property enhancement. Polysaccharide-based scaffolds support chondrogenesis, regulate inflammation, and promote tissue regeneration, making them ideal candidates for cartilage repair. Functionalization with antimicrobial agents and bioactive molecules further improves their efficacy by preventing infection and promoting cell attachment and differentiation. However, challenges related to scalability, biocompatibility, stability in vivo, and cost-effective production remain exist. The review also discusses emerging trends, including the integration of 3D bioprinting, nanomaterials, and combination therapies to enhance polysaccharide-based scaffolds for cartilage repair. The future of polysaccharide-based scaffolds holds great promise in advancing cartilage tissue engineering toward clinical applications.

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.