冲击和阻力运动对Wnt信号调节剂、骨和软骨代谢的急性影响。

IF 5.9 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Benjamin Boxer, Zhuoyue Zhang, Jonathan P Folland, Richard Eastell, Fatma Gossiel, Ogulcan Caliskan, Katherine Brooke-Wavell
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引用次数: 0

摘要

冲击和阻力运动具有强大的成骨作用,并可能通过组织变形对软骨产生积极影响。这些作用可能是通过Wnt信号的抑制剂如sclerostin和Dickkopf Wnt信号通路抑制剂1 (DKK1)介导的,它们也可能在软骨代谢中发挥作用。本研究评估了急性冲击和阻力运动对骨转换、信号和软骨代谢的生物标志物的影响。健康的年轻男性按随机顺序完成冲击或阻力训练和对照试验。冲击练习包括120次最大努力的多向跳跃和跳跃。阻力训练包括120次高负荷下肢举举。跳跃和提升穿插着1-3秒的停顿。在对照试验中,受试者采用与运动试验相同的仰卧姿势休息。在运动/休息前、立即和24 h后采集血样,分析硬化蛋白、DKK1、I型胶原c端端肽(CTX-I)、I型前胶原n端前肽(PINP)、II型前胶原c端前肽(PIICP)和软骨寡聚基质蛋白(COMP)。重复测量方差分析比较时间点、试验及其相互作用。参与者为26名男性,平均(SD)年龄23.4(2.9)岁。冲击运动增加运动后立即的PINP(平均[95%CI] +10.8[4.8,17.2]%, p =。002)和24 h后(+7.4[0.0,15.3]%,p =。05),而阻力运动则没有效果。仅在冲击运动试验中,运动后硬化蛋白瞬间升高(+36.3[24.6,49.3]%,p
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Acute effect of impact and resistance exercise on Wnt signaling modulators, bone and cartilage metabolism.

Impact and resistance exercise have potent osteogenic effects and may positively affect cartilage through tissue deformation. These effects may be mediated through inhibitors of Wnt signaling such as sclerostin and Dickkopf WNT signaling pathway inhibitor 1 (DKK1), which may also play a role in cartilage metabolism. This study evaluated the effect of acute bouts of impact and resistance exercise on biomarkers of bone turnover, signaling, and cartilage metabolism. Healthy young men completed impact or resistance exercise and a control trial in random order. Impact exercise involved 120 maximum-effort multidirectional jumps and hops. Resistance exercise involved 120 high load lower limb lifts. Jumps and lifts were interspersed with 1-3 s pauses. In control trial, participants rested in a supine position for same duration as exercise trial. Blood samples were taken pre, immediately and 24 h post exercise/rest and analyzed for sclerostin, DKK1, C-terminal telopeptide of type I collagen (CTX-I), procollagen I N-terminal propeptide (PINP), procollagen II C-terminal propeptide (PIICP) and cartilage oligomeric matrix protein (COMP). Repeated measures ANOVA compared time points, trials and their interaction. Participants were 26 men, mean (SD) age 23.4 (2.9) years. Impact exercise increased PINP immediately post exercise (by mean [95%CI] +10.8[4.8,17.2]%, p = .002) and 24 h later (+7.4[0.0,15.3]%, p = .05) whereas resistance exercise had no effect. A transient increase in sclerostin immediately post exercise occurred in the impact exercise trial only (+36.3[24.6,49.3]%, p < .001). Both exercise modes transiently increased DKK1 immediately post exercise (impact +32.4[23.1,42.4]%, p < .001; resistance +30.3[22.8,38.4]%, p < .001). COMP increased immediately after resistance exercise only (+36.2[16.0,59.8]%, p < .001). Neither form of exercise affected CTX-I. Impact and resistance exercise transiently increased Wnt signaling inhibitors. Resistance exercise increased a marker of cartilage turnover but did not affect markers of bone turnover. Impact exercise did not affect cartilage turnover markers. Increases in bone formation but not resorption markers may reflect positive adaptation to impact loading.

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来源期刊
Journal of Bone and Mineral Research
Journal of Bone and Mineral Research 医学-内分泌学与代谢
CiteScore
11.30
自引率
6.50%
发文量
257
审稿时长
2 months
期刊介绍: The Journal of Bone and Mineral Research (JBMR) publishes highly impactful original manuscripts, reviews, and special articles on basic, translational and clinical investigations relevant to the musculoskeletal system and mineral metabolism. Specifically, the journal is interested in original research on the biology and physiology of skeletal tissues, interdisciplinary research spanning the musculoskeletal and other systems, including but not limited to immunology, hematology, energy metabolism, cancer biology, and neurology, and systems biology topics using large scale “-omics” approaches. The journal welcomes clinical research on the pathophysiology, treatment and prevention of osteoporosis and fractures, as well as sarcopenia, disorders of bone and mineral metabolism, and rare or genetically determined bone diseases.
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